International Partnership for Microbicides
Pre-Approval PRO BETAStale Activity
No new clinical trials started in 2+ years. Activity may be declining or company may be focusing on existing programs. Last trial started: 8/1/2022
Pipeline by Phase
Therapeutic Focus
Clinical Trials (34)
Phase 3 Safety and Effectiveness Trial of Dapivirine Vaginal Ring for Prevention of HIV-1 in Women
Started: 7/24/2012
To Assess Continued Safety of and Adherence to the Dapivirine (25 mg) Vaginal Ring-004 in Healthy, HIV-negative Women
Started: 7/12/2016
Trial to Assess the Continued Safety of and Adherence to a Vaginal Ring Containing Dapivirine in Women
Started: 7/18/2016
A Safety and Efficacy Trial of Dapivirine Vaginal Ring in Africa
Started: 7/1/2011
A Safety and Efficacy Trial of Dapivirine Vaginal Ring in Africa
Started: 7/1/2011
Safety and Pharmacokinetics of Dapivirine Vaginal Ring in Post-menopausal Women
Started: 12/1/2013
Study of Dapivirine Vaginal Ring (VR) in Adolescents
Started: 6/27/2014
Reversing the Epidemic in Africa With Choices in HIV Prevention (REACH)
Started: 11/1/2017
PK, Safety Study of 90-Day Use of Vaginal Rings Containing Dapivirine and Levonorgestrel
Started: 6/20/2022
Relative Bioavailability Trial of Dapivirine Ring-004 and Ring-008
Started: 8/1/2022
A Safety Study of Two Dapivirine (TMC120) Vaginal Gels in the United States
Started: 7/6/2009
PK Study of 90-Day Use of Vaginal Rings Containing Dapivirine and Levonorgestrel
Started: 7/17/2018
A Phase 1, Randomized Pharmacokinetics and Safety Study of Extended Duration Dapivirine Vaginal Rings
Started: 12/4/2017
PK and Safety Study of Vaginal Rings Containing Dapivirine and Levonorgestrel
Started: 5/3/2017
Functionality of Male Condoms With a Silicone Elastomer Vaginal RIng
Started: 2/1/2013
Pharmacokinetic Study of the Dapivirine Vaginal Ring in Lactating Women
Started: 2/1/2015
A Trial to Assess the Functionality of Female Condom With a Silicone Elastomer Vaginal Ring
Started: 8/1/2013
Safety and Pharmacokinetic Trial in Healthy HIV-Negative Women to Assess the Delivery of Dapivirine From a Vaginal Ring
Started: 8/1/2009
DDI Potential: Dapivirine Vaginal Ring and Miconazole Nitrate
Started: 12/1/2012
Assessing the Safety of Dapivirine Gel and Film Formulations
Started: 8/1/2012
Male Tolerance Study of Dapivirine Gel Following Multiple Topical Penile Exposures
Started: 3/1/2011
Safety and Pharmacokinetic Study of Oral Maraviroc and Maraviroc 1% Gel in HIV-1 Seronegative Adults
Started: 1/1/2015
A Trial In Healthy HIV-Negative Women To Assess The Effect Of Menses And Tampon Use On The Pharmacokinetics Of Dapivirine, Delivered By Dapivirine Vaginal Ring-004, Containing 25 Mg Of Dapivirine
Started: 1/12/2015
To Assess the Drug-drug Interaction Potential Between Dapivirine Vaginal Ring-004, Containing 25 mg of Dapivirine, and Clotrimazole 10 mg/g (1%)
Started: 9/1/2015
Evaluate the Safety & Assess Local and Systemic PK of DS003 Vaginal Tablets Administered to Healthy HIV-negative Women
Started: 11/18/2015
Safety and Pharmacokinetics of Dapivirine/Maraviroc Vaginal Ring
Started: 11/1/2011
An Expanded Safety Study of Dapivirine Gel 4789 in Africa
Started: 7/1/2009
An Expanded Safety Study of Dapivirine Gel 4759 in Africa
Started: 11/1/2009
A Safety and Pharmacokinetic Study for Dapivirine and Maraviroc Gel in Belgium
Started: 1/1/2011
A Safety Study to Assess the Delivery of Dapivirine From a Matrix Vaginal Ring
Started: 4/1/2010