TheraRadar
Clinical-Stage Companies / MacroGenics

MacroGenics

Pre-Approval PRO BETA
36
Total Trials
4
Phase 3
14
Phase 2
5
Recruiting
252
Score

Pipeline by Phase

Phase 3
4
Phase 2
14
Phase 1
25

Therapeutic Focus

Melanoma Non Small Cell Lung Cancer Squamous Cell Carcinoma of Head and Neck Gastric Cancer Breast Cancer

Clinical Trials (36)

NCT02492711 Phase 3 COMPLETED

Margetuximab Plus Chemotherapy vs Trastuzumab Plus Chemotherapy in the Treatment of HER2+ Metastatic Breast Cancer

Started: 8/24/2015

NCT00920582 Phase 3 TERMINATED

Protege Encore Study- Clinical Trial of Teplizumab (MGA031) in Children and Adults With Recent-Onset Type 1 Diabetes Mellitus

Started: 9/1/2009

NCT06730347 Phase 2 RECRUITING

A Study of Lorigerlimab in Participants With Advanced Solid Tumors

Started: 5/1/2025

NCT05848011 Phase 2 COMPLETED

A Study of Lorigerlimab With Docetaxel or Docetaxel Alone in Participants With Metastatic Castration-Resistant Prostate Cancer

Started: 9/28/2023

NCT05551117 Phase 2 TERMINATED

A Study of Vobramitamab Duocarmazine in Participants With Metastatic Castration Resistant Prostate Cancer and Other Solid Tumors

Started: 6/13/2023

NCT04082364 Phase 2 COMPLETED

Combination Margetuximab, Retifanlimab, Tebotelimab, and Chemotherapy Phase 2/3 Trial in HER2+ Gastric/GEJ Cancer

Started: 9/30/2019

NCT01828021 Phase 2 COMPLETED

Phase 2 Study of the Monoclonal Antibody MGAH22 (Margetuximab) in Patients With Relapsed or Refractory Advanced Breast Cancer

Started: 3/1/2013

NCT04634825 Phase 2 TERMINATED

Enoblituzumab Plus Retifanlimab or Tebotelimab in Head and Neck Cancer

Started: 3/17/2021

NCT00625586 Phase 2 TERMINATED

Monoclonal Antibody RAV12 and Gemcitabine in Treating Patients With Metastatic Pancreatic Cancer

Started: 4/15/2008

NCT00927953 Phase 2 TERMINATED

Treatment of West Nile Virus With MGAWN1

Started: 5/1/2009

NCT04129320 Phase 2 WITHDRAWN

Enoblituzumab Plus MGA012 or MGD013 in Squamous Cell Carcinoma of the Head and Neck

Started: 10/1/2019

NCT06723236 Phase 1 RECRUITING

A Study of MGC028 in Participants With Advanced Solid Tumors

Started: 2/13/2025

NCT06242470 Phase 1 RECRUITING

A Study of MGC026 in Participants With Advanced Solid Tumors

Started: 3/6/2024

NCT07822399 Phase 1 RECRUITING

A Study of MGC030 in Participants With Advanced Solid Tumors

Started: 10/7/2026

NCT05362773 Phase 1 ACTIVE NOT RECRUITING

A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies

Started: 7/13/2022

NCT05293496 Phase 1 COMPLETED

A Study of MGC018 in Combination With MGD019 in Participants With Advanced Solid Tumors

Started: 4/19/2022

NCT02475213 Phase 1 COMPLETED

Safety Study of Enoblituzumab (MGA271) in Combination With Pembrolizumab or MGA012 in Refractory Cancer

Started: 7/1/2015

NCT03729596 Phase 1 TERMINATED

MGC018 With or Without MGA012 in Advanced Solid Tumors

Started: 11/21/2018

NCT05261191 Phase 1 COMPLETED

A Study of MGD020 Alone or Combined With MGD014 in Persons With HIV-1 on Antiretroviral Therapy

Started: 9/26/2022

NCT02689284 Phase 1 COMPLETED

Combination Margetuximab and Pembrolizumab for Advanced, Metastatic HER2(+) Gastric or Gastroesophageal Junction Cancer

Started: 1/1/2016

NCT03761017 Phase 1 COMPLETED

MGD019 DART® Protein in Unresectable/Metastatic Cancer

Started: 12/12/2018

NCT01148849 Phase 1 COMPLETED

Safety Study of MGAH22 in HER2-positive Carcinomas

Started: 7/1/2010

NCT02152956 Phase 1 TERMINATED

Flotetuzumab in Primary Induction Failure (PIF) or Early Relapse (ER) Acute Myeloid Leukemia (AML)

Started: 6/9/2014

NCT03219268 Phase 1 COMPLETED

A Study of MGD013 in Patients With Unresectable or Metastatic Neoplasms

Started: 8/18/2017

NCT03570918 Phase 1 COMPLETED

MGD014 in HIV-Infected Individuals on Suppressive Antiretroviral Therapy

Started: 9/25/2018

NCT03406949 Phase 1 COMPLETED

MGD009/MGA012 Combination in Relapsed/Refractory Cancer

Started: 2/27/2018

NCT00954915 Phase 1 TERMINATED

Safety Study of the Monoclonal Antibody Teplizumab (MGA031) in Subjects With Moderate or More Severe Psoriasis

Started: 12/1/2009

NCT01391143 Phase 1 COMPLETED

Safety Study of MGA271 in Refractory Cancer

Started: 7/1/2011

NCT03531632 Phase 1 COMPLETED

MGD007 Combined With MGA012 in Relapsed/Refractory Metastatic Colorectal Cancer

Started: 6/4/2018

NCT02381314 Phase 1 COMPLETED

Safety Study of Enoblituzumab (MGA271) in Combination With Ipilimumab in Refractory Cancer

Started: 3/26/2015

NCT02376036 Phase 1 COMPLETED

Phase 1 Study of MGD010 in Healthy Subjects

Started: 2/1/2015

NCT02248805 Phase 1 COMPLETED

Phase 1 Study of MGD007 in Relapsed/Refractory Metastatic Colorectal Carcinoma

Started: 10/1/2014

NCT01189422 Phase 1 TERMINATED

Subcutaneous Administration of Teplizumab in Adults With Type 1 Diabetes

Started: 8/1/2010

NCT02982941 Phase 1 COMPLETED

Enoblituzumab (MGA271) in Children With B7-H3-expressing Solid Tumors

Started: 12/1/2016

NCT01918930 Phase 1 TERMINATED

Tissue Procurement Substudy for Participants in Study CP-MGA271-01

Started: 7/1/2013

NCT02628535 Phase 1 TERMINATED

Safety Study of MGD009 in B7-H3-expressing Tumors

Started: 9/1/2015

Drug Candidates

MGC028 lorigerlimab Lorigerlimab vobramitamab duocarmazine 2.0 mg (Arm A) vobramitamab duocarmazine 2.7 mg (Arm B) vobramitamab duocarmazine MGC026 Dose Escalation MGC026 Dose for Expansion Pembrollizumab vobramitamab tavatecan
Activity Status: Active
Last Trial Started: 10/7/2026
Last Trial Ended: 3/16/2026
Trials (12 months): 1
Completed Trials: 19
Data sourced from ClinicalTrials.gov. This company has no FDA-approved drugs.