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Clinical-Stage Companies / Revolution Medicines

Revolution Medicines

Pre-Approval PRO BETA
15
Total Trials
4
Phase 3
7
Phase 2
12
Recruiting
171
Score

Pipeline by Phase

Phase 3
4
Phase 2
7
Phase 1
10

Therapeutic Focus

Colorectal Cancer (CRC) PDAC Pancreatic Cancer Pancreatic Ductal Adenocarcinoma (PDAC) Advanced Solid Tumors

Clinical Trials (15)

NCT07252232 Phase 3 RECRUITING

Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)

Started: 12/15/2025

NCT07491445 Phase 3 RECRUITING

Study of Daraxonrasib and Daraxonrasib + GnP as First-line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma

Started: 3/9/2026

NCT06881784 Phase 3 RECRUITING

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

Started: 5/6/2025

NCT06625320 Phase 3 ACTIVE NOT RECRUITING

Phase 3 Study of Daraxonrasib (RMC-6236) in Patients With Previously Treated Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)

Started: 10/16/2024

NCT05054725 Phase 2 COMPLETED

Combination Study of RMC-4630 and Sotorasib for NSCLC Subjects With KRASG12C Mutation After Failure of Prior Standard Therapies

Started: 12/30/2021

NCT06445062 Phase 1 RECRUITING

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

Started: 5/24/2024

NCT07397338 Phase 1 RECRUITING

Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors

Started: 1/30/2026

NCT06162221 Phase 1 RECRUITING

Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC

Started: 1/18/2024

NCT06128551 Phase 1 RECRUITING

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

Started: 11/14/2023

NCT07349537 Phase 1 RECRUITING

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

Started: 1/8/2026

NCT05379985 Phase 1 RECRUITING

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

Started: 5/31/2022

NCT06040541 Phase 1 RECRUITING

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

Started: 9/7/2023

NCT05462717 Phase 1 ACTIVE NOT RECRUITING

Dose Escalation and Dose Expansion Study of RMC-6291 Monotherapy in Subjects With Advanced KRASG12C Mutant Solid Tumors

Started: 9/19/2022

NCT04774952 Phase 1 COMPLETED

Dose Escalation of RMC-5552 Monotherapy in Relapsed/Refractory Solid Tumors

Started: 4/7/2021

NCT03989115 Phase 1 COMPLETED

Dose-Esc/Exp RMC4630 & Cobi in Relapsed/Refractory Solid Tumors & RMC4630& Osi in EGFR+ Locally Adv/Meta NSCLC

Started: 7/2/2019

Drug Candidates

RMC-6291 daraxonrasib gemcitabine nab-paclitaxel RMC-6236 mFOLFOX6 regimen bevacizumab mFOLFIRINOX regimen cetuximab RMC-9805
Activity Status: Active
Last Trial Started: 3/9/2026
Last Trial Ended: 8/29/2024
Trials (12 months): 5
Completed Trials: 3
Data sourced from ClinicalTrials.gov. This company has no FDA-approved drugs.