Anchored on CT.gov primary completion date. Topline announcements typically precede this by 3–9 months. Confidence labels combine date type (ACTUAL/ESTIMATED) with last-update freshness.

Treatments by Mechanism

Top 12 mechanisms across 54 industry trials with a known mechanism of action.

See full pipeline →

SGLT2

5 trials 1 active 3 sponsors

Sodium-Glucose Cotransporter 2 Inhibitor

5 trials 1 active 2 sponsors

CaSR

4 trials 1 active 1 sponsor

Parenteral Iron Replacement

3 trials 1 active 1 sponsor

Glucose-dependent Insulinotropic Polypeptide Receptor Agonist

2 trials 1 active 1 sponsor

Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitor

14 trials 1 sponsor

Vitamin D2 Analog

6 trials 3 sponsors

Erythropoiesis-stimulating Agent

5 trials 2 sponsors

ferric reductase/phosphate

4 trials 2 sponsors

Erythropoietin Receptor

2 trials 2 sponsors

GLP-1 Receptor Agonist

2 trials 2 sponsors

Kinase Inhibitor

2 trials 1 sponsor

MoA derived from FDA pharmClassEpc when intervention matches an approved drug. Codenamed clinical-stage assets without an approved counterpart show "—" and aren't grouped here — they're still in the phase tables below.

Clinical Pipeline by Phase

531 industry-sponsored trials across 179 sponsors

View full landscape →

Showing 30 of 30 trials

Sponsor	Asset	MoA	Status	Primary Completion	NCT
Ace Cells Lab Limited	ACE Reno	—	RECRUITING	2026-08-31	NCT07187713
Zydus Lifesciences Limited	Desidustat	—	RECRUITING	2025-06-30	NCT05515367
AstraZeneca	Dapagliflozin	SGLT2	ACTIVE NOT RECRUITING	2027-05-31	NCT06610526
Xuanzhu Biopharmaceutical Co., Ltd.	Anaprazole Sodium enteric-coated tablet	—	NOT YET RECRUITING	2026-10-30	NCT07345689
Shenzhen Salubris Pharmaceuticals Co., Ltd.	Enarodustat 2mg	—	NOT YET RECRUITING	2027-06	NCT07079579
Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.	ganagliflozin	—	NOT YET RECRUITING	2031-10-30	NCT07116928
Bayer	Finerenone (Kerendia, BAY94-8862)	—	COMPLETED	2025-07-03	NCT05705271
AstraZeneca	Sodium Zirconium Cyclosilicate (SZC)	—	COMPLETED	2024-12-10	NCT05347693
Ardelyx	Tenapanor	—	COMPLETED	2021-10-13	NCT04549597
AstraZeneca	Roxadustat	—	COMPLETED	2021-10-12	NCT04655027
Keryx Biopharmaceuticals	KRX-0502	—	COMPLETED	2019-08-30	NCT03236246
Sumitomo Pharma (Suzhou) Co., Ltd.	Arotinolol Hydrochloride	—	COMPLETED	2018-10-10	NCT01351636
Novartis	Induction therapy	—	COMPLETED	2017-02-01	NCT01950819
Amgen	Epoetin alfa	Erythropoietin Receptor	COMPLETED	2016-04-27	NCT02253654
AbbVie (prior sponsor, Abbott)	Paricalcitol	Vitamin D2 Analog [EPC]	COMPLETED	2016-04-07	NCT01506947
AMAG Pharmaceuticals, Inc.	Ferumoxytol	Parenteral Iron Replacement [EPC]	COMPLETED	2016-02	NCT01227616
Yuhan Corporation	Anplag(Sarpogrelate)	—	COMPLETED	2014-11-17	NCT01869881
Fresenius Medical Care Korea	—	—	COMPLETED	2014-04	NCT01997385
GE Healthcare	Omniscan	Paramagnetic Contrast Agent [EPC]	COMPLETED	2013-06	NCT00908310
Otsuka Beijing Research Institute	Probucol	—	COMPLETED	2012-12	NCT01252056
Fresenius Medical Care North America	Calcium acetate oral solution (COS)	—	COMPLETED	2012-07	NCT01427907
Guerbet	Dotarem®-enhanced MRI	—	COMPLETED	2011-05	NCT00650845
Abbott	Paricalcitol	Vitamin D2 Analog [EPC]	COMPLETED	2011-05	NCT00977080
Novo Nordisk	—	—	COMPLETED	2011-04	NCT01245374
Amgen	Cinacalcet	—	COMPLETED	2010-12-09	NCT00803712
Abbott	Zemplar (paricalcitol)	—	COMPLETED	2010-09	NCT00891813
Novartis	HX575 recombinant human erythropoietin alfa	—	COMPLETED	2010-03	NCT00632125
Ironwood Pharmaceuticals, Inc.	Lesinurad	—	TERMINATED	2019-02-25	NCT03226899
GE Healthcare	Visipaque	—	TERMINATED	2018-09-13	NCT03119662
B. Braun Melsungen AG	HES 130/0.42 + electrolyte solution	—	TERMINATED	2010-09	NCT00936247

Showing 100 of 163 trials (top 100 by completion date — export for full list)

Sponsor	Asset	MoA	Status	Primary Completion	NCT
Alebund Pharmaceuticals	AP301	—	RECRUITING	2026-06-20	NCT06933472
AMAG Pharmaceuticals, Inc.	Ferumoxytol	Parenteral Iron Replacement [EPC]	RECRUITING	2026-08-31	NCT03619850
Kind Pharmaceuticals LLC	AND017 capsules	—	RECRUITING	2026-10-30	NCT07494409
Shaanxi Micot Pharmaceutical Technology Co., Ltd.	MT1013	—	RECRUITING	2026-11-26	NCT07122401
Genexine, Inc.	Efepoetin Alfa	—	RECRUITING	2026-12	NCT06466785
Kind Pharmaceuticals LLC	AND017	—	RECRUITING	2026-12-01	NCT07487727
Renibus Therapeutics, Inc.	Veverimer	—	RECRUITING	2027-06	NCT07355062
Bayer	Finerenone (Kerendia, BAY94-8862)	—	RECRUITING	2027-07-31	NCT05196035
Astellas Pharma Global Development, Inc.	Roxadustat	—	RECRUITING	2027-10-30	NCT05970172
Boehringer Ingelheim	Empagliflozin	Sodium-Glucose Cotransporter 2 Inhibitor [EPC]	RECRUITING	2028-06-26	NCT07107945
Bayer	Finerenone (Kerendia, BAY94-8862)	—	RECRUITING	2029-01-28	NCT05457283
Amgen	Etelcalcetide	CaSR	RECRUITING	2029-01-31	NCT03633708
Prokidney	Renal Autologous Cell Therapy (REACT/ rilparencel)	—	RECRUITING	2029-12	NCT05099770
Shandong Suncadia Medicine Co., Ltd.	HRS-1780 tablets	—	RECRUITING	2030-04	NCT07419828
Eli Lilly	Orforglipron	—	RECRUITING	2031-08	NCT07241390
Biocad	BCD-131 (pegdarbepoetin beta)	—	RECRUITING	2026-05	NCT07119372
Novo Nordisk	Ziltivekimab B	—	ACTIVE NOT RECRUITING	2026-06-09	NCT05021835
Akebia Therapeutics	Erythropoiesis-Stimulating Agent (ESA)	—	ACTIVE NOT RECRUITING	2026-08	NCT06901505
AstraZeneca	Zibotentan/Dapagliflozin	—	ACTIVE NOT RECRUITING	2027-02-18	NCT06087835
Eli Lilly	Retatrutide	—	ACTIVE NOT RECRUITING	2029-02	NCT06383390
AstraZeneca	Ravulizumab	—	ACTIVE NOT RECRUITING	2026-05-18	NCT05746559
Daewoong Pharmaceutical Co. LTD.	DWP16001 0.3mg	—	NOT YET RECRUITING	2026-09-01	NCT06606093
Ebima Clifford Okundaye	QRX-3	—	NOT YET RECRUITING	2026-10	NCT06866236
Megalabs	Experimental: Epoetin alfa Megalabs® Erythropoietin injectable in intravenous administration.	—	NOT YET RECRUITING	2027-03	NCT06352138
Eli Lilly	Orforglipron	—	COMPLETED	2026-03-16	NCT05803421
Bayer	Finerenone (BAY94-8862)	—	COMPLETED	2025-12-31	NCT05047263
Vifor Fresenius Medical Care Renal Pharma	Patiromer Powder for Oral Suspension (Part A)	—	COMPLETED	2025-11-18	NCT05136664
Bayer	Finerenone	Nonsteroidal Mineralocorticoid-Receptor Antagonist [EPC]	COMPLETED	2025-08-20	NCT05901831
Novo Nordisk	Semaglutide	GLP-1 Receptor Agonist [EPC]	COMPLETED	2024-11-21	NCT04865770
Alebund Pharmaceuticals	AP301	—	COMPLETED	2024-10-02	NCT07030595
Serodus AS	SER150	—	COMPLETED	2024-06-06	NCT04881123
Galderma R&D	Nemolizumab	—	COMPLETED	2024-01-04	NCT05075408
MediBeacon	MB-102	—	COMPLETED	2023-02-15	NCT05425719
Akebia Therapeutics	Vadadustat	Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitor [EPC]	COMPLETED	2023-01-06	NCT04707768
Nanogen Pharmaceutical Biotechnology Joint Stock Company	Stimus (NNG-DEPO)	—	COMPLETED	2022-11-23	NCT05585645
Panion & BF Biotech Inc.	Ferric citrate	ferric reductase/phosphate	COMPLETED	2022-10-28	NCT04543812
Boehringer Ingelheim	Empagliflozin	Sodium-Glucose Cotransporter 2 Inhibitor [EPC]	COMPLETED	2022-07-05	NCT03594110
PT Kalbe Genexine Biologics	efepoetin alfa	—	COMPLETED	2022-03-30	NCT04155125
Shenzhen Salubris Pharmaceuticals Co., Ltd.	SAL-0951	—	COMPLETED	2021-10-08	NCT06016036
Zydus Lifesciences Limited	Desidustat Oral Tablet	—	COMPLETED	2021-09-02	NCT04215120
Zydus Lifesciences Limited	Desidustat Oral Tablet	—	COMPLETED	2021-08-25	NCT04012957
Bio Sidus SA	Erythropoietin alfa	—	COMPLETED	2021-06-15	NCT04036253
Jiangsu Hansoh Pharmaceutical Co., Ltd.	Pegol-Sihematide	—	COMPLETED	2021-02-28	NCT03902691
JW Pharmaceutical	JTZ-951	—	COMPLETED	2021-02-23	NCT04027517
Bayer	Finerenone (BAY94-8862)	—	COMPLETED	2021-02-02	NCT02545049
Tanabe Pharma Corporation	Canagliflozin	SGLT2	COMPLETED	2021-01-21	NCT03436693
Vifor Fresenius Medical Care Renal Pharma	PA21	—	COMPLETED	2020-08-21	NCT03644264
Akebia Therapeutics	Vadadustat	Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitor [EPC]	COMPLETED	2020-06-18	NCT02680574
AstraZeneca	Dapagliflozin	SGLT2	COMPLETED	2020-06-12	NCT03036150
Akebia Therapeutics	Vadadustat	Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitor [EPC]	COMPLETED	2020-06-04	NCT02648347
Bayer	Finerenone (BAY94-8862)	—	COMPLETED	2020-04-14	NCT02540993
Amgen	Etelcalcetide	CaSR	COMPLETED	2020-04-08	NCT03299244
Akebia Therapeutics	Vadadustat	Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitor [EPC]	COMPLETED	2020-01-31	NCT02865850
Akebia Therapeutics	Vadadustat	Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitor [EPC]	COMPLETED	2020-01-16	NCT02892149
Boryung Pharmaceutical Co., Ltd	Fimsartan 60mg~120mg	—	COMPLETED	2019-12-23	NCT02620306
Astellas Pharma Inc	roxadustat	—	COMPLETED	2019-09-13	NCT02988973
Bayer	Molidustat (BAY85-3934)	—	COMPLETED	2019-08-07	NCT03543657
Bayer	Molidustat (BAY85-3934)	—	COMPLETED	2019-07-25	NCT03418168
Bayer	Molidustat (BAY85-3934)	—	COMPLETED	2019-07-05	NCT03350347
Bayer	Molidustat (BAY85-3934)	—	COMPLETED	2019-05-17	NCT03350321
Lexicon Pharmaceuticals	Sotagliflozin	Sodium-Glucose Cotransporter 2 Inhibitor [EPC]	COMPLETED	2019-05-16	NCT03242018
Lexicon Pharmaceuticals	Sotagliflozin	Sodium-Glucose Cotransporter 2 Inhibitor [EPC]	COMPLETED	2019-03-25	NCT03242252
Tanabe Pharma Corporation	MT-6548	—	COMPLETED	2019-01-08	NCT03329196
Tanabe Pharma Corporation	MT-6548	—	COMPLETED	2018-12-12	NCT03439137
Tanabe Pharma Corporation	MT-6548	—	COMPLETED	2018-12-03	NCT03461146
Tanabe Pharma Corporation	MT-6548	—	COMPLETED	2018-11-22	NCT03402386
Johnson & Johnson	Canagliflozin	SGLT2	COMPLETED	2018-10-30	NCT02065791
Bayer	Molidustat (BAY85-3934)	—	COMPLETED	2018-10-23	NCT03351166
Astellas Pharma Inc	roxadustat	—	COMPLETED	2018-08-15	NCT02964936
Pharmacosmos A/S	Iron isomaltoside/ferric derisomaltose	—	COMPLETED	2018-05-29	NCT02940860
Astellas Pharma Europe B.V.	Roxadustat	—	COMPLETED	2018-03-23	NCT02021318
Astellas Pharma Inc	roxadustat	—	COMPLETED	2018-03-13	NCT02952092
Proteon Therapeutics	Vonapanitase	—	COMPLETED	2018-02	NCT02414841
Shield Therapeutics	Ferric maltol	—	COMPLETED	2018-01-18	NCT02968368
Astellas Pharma Inc	roxadustat	—	COMPLETED	2017-12-12	NCT02780141
Astellas Pharma Europe B.V.	Roxadustat	—	COMPLETED	2017-11-01	NCT01887600
Amgen	Darbepoetin alfa	Erythropoiesis-stimulating Agent [EPC]	COMPLETED	2017-10-19	NCT01652872
Astellas Pharma Inc	roxadustat	—	COMPLETED	2017-08-02	NCT02780726
Chong Kun Dang Pharmaceutical	CKD-11101	—	COMPLETED	2017-06	NCT03428594
Otsuka Pharmaceutical Development & Commercialization, Inc.	Tolvaptan (OPC-41061)	—	COMPLETED	2017-04-18	NCT02160145
Amgen	Cinacalcet	—	COMPLETED	2017-03-15	NCT02341417
Chong Kun Dang Pharmaceutical	CKD-11101(Darbepoetin alfa)	—	COMPLETED	2017-02	NCT03431623
Biocad	Darbepoetin alfa	Erythropoiesis-stimulating Agent [EPC]	COMPLETED	2017-01-08	NCT02506868
Proteon Therapeutics	PRT-201	—	COMPLETED	2016-12	NCT02110901
Pfizer	Epoetin Hospira Arm	—	COMPLETED	2016-07-02	NCT02504294
Eli Lilly	Dulaglutide	GLP-1 Receptor Agonist [EPC]	COMPLETED	2016-06	NCT01621178
Keryx Biopharmaceuticals	ferric citrate	ferric reductase/phosphate	COMPLETED	2016-01	NCT02268994
Novartis	Valsartan	Angiotensin 2 Receptor Blocker [EPC]	COMPLETED	2015-09	NCT01365481
OPKO Health, Inc.	CTAP101 Capsules	—	COMPLETED	2015-05	NCT02282813
Fresenius Medical Care Deutschland GmbH	Osvaren Granules	—	COMPLETED	2015-04	NCT02027662
Astellas Pharma Inc	ASP1585	—	COMPLETED	2015-04	NCT01742611
Amgen	Etelcalcetide	CaSR	COMPLETED	2014-11-12	NCT01896232
Novartis	HX575 epoetin alfa (Sandoz)	—	COMPLETED	2014-10	NCT01576341
OPKO IP Holdings II, Inc.	CTAP101 30 μg capsules	—	COMPLETED	2014-08	NCT01704079
OPKO IP Holdings II, Inc.	CTAP101 30 μg capsules	—	COMPLETED	2014-07	NCT01651000
Pharmacosmos A/S	Monofer	—	COMPLETED	2014-06	NCT01102413
AbbVie (prior sponsor, Abbott)	Paricalcitol	Vitamin D2 Analog [EPC]	COMPLETED	2014-05	NCT01020487
Novartis	HX575 epoetin alfa	—	COMPLETED	2014-05	NCT01693029
Astellas Pharma Inc	ASP1585	—	COMPLETED	2014-05	NCT01742585
Pfizer	Epoetin Hospira	—	COMPLETED	2014-02-28	NCT01473420

Showing 100 of 177 trials (top 100 by completion date — export for full list)

Sponsor	Asset	MoA	Status	Primary Completion	NCT
AstraZeneca	Zibotentan/Dapagliflozin	—	RECRUITING	2026-07-31	NCT06942910
Novo Nordisk	NNC0519-0130	—	RECRUITING	2026-09-01	NCT06717698
Ingenia Therapeutics INC	IGT-303	—	RECRUITING	2026-10	NCT07231679
River 3 Renal Corp.	R3R01	—	RECRUITING	2026-10	NCT06600412
AION Healthspan, Inc.	AION-301	—	RECRUITING	2027-01	NCT06721143
PT. Prodia Stem Cell Indonesia	Umbilical Cord Mesenchymal Stem Cells	—	RECRUITING	2027-07	NCT07396155
Regeneron	ALN-ANG3	—	RECRUITING	2027-09-24	NCT07271186
Regeneron	Vonsetamig	—	RECRUITING	2027-11-22	NCT05092347
Vifor Fresenius Medical Care Renal Pharma	Difelikefalin	—	RECRUITING	2029-08-15	NCT06593392
The United Bio-Technology (Hengqin) Co., Ltd.	UBT251	—	RECRUITING	2030-07-11	NCT07134335
Shaanxi Micot Pharmaceutical Technology Co., Ltd.	MT1013	—	RECRUITING	2025-08-19	NCT06976177
Boehringer Ingelheim	Vicadrostat	—	ACTIVE NOT RECRUITING	2026-08-20	NCT06926660
Eli Lilly	Tirzepatide	Glucose-dependent Insulinotropic Polypeptide Receptor Agonist [EPC]	ACTIVE NOT RECRUITING	2026-09	NCT05536804
Biocity Biopharmaceutics Co., Ltd.	SC0062 low dose	—	ACTIVE NOT RECRUITING	2024-11-30	NCT05687890
PT. JES Kasih Nusantara Sejahterah	Dendritic cell immunotherapy	—	ACTIVE NOT RECRUITING	2024-08-05	NCT06866158
Novartis	Atrasentan	—	ACTIVE NOT RECRUITING	2024-07-02	NCT04573920
R1 Therapeutics	AP306 75 mg BID	—	NOT YET RECRUITING	2027-02-28	NCT06712654
Atom Therapeutics Co., Ltd	ABP-671 plus febuxostat Group 1	—	NOT YET RECRUITING	2027-10-31	NCT07323095
Jiangsu Hansoh Pharmaceutical Co., Ltd.	HS-10390	—	NOT YET RECRUITING	2027-11-11	NCT07555054
Shanghai Hengrui Pharmaceutical Co., Ltd.	SHR6508	—	COMPLETED	2025-11-13	NCT06236295
Bayer	BAY3283142	—	COMPLETED	2025-10-24	NCT06522997
Shaanxi Micot Pharmaceutical Technology Co., Ltd.	MT1013	—	COMPLETED	2025-10-15	NCT06690242
Eli Lilly	Retatrutide	—	COMPLETED	2025-10-01	NCT05936151
Novo Nordisk	Cagrilintide	—	COMPLETED	2025-09-24	NCT06131372
Revelation Biosciences, Inc	Intravenous Gemini	—	COMPLETED	2025-07-22	NCT06863467
Prokidney	Renal Autologous Cell Therapy (REACT)	—	COMPLETED	2025-05-20	NCT05018416
Shaanxi Micot Pharmaceutical Technology Co., Ltd.	Long-term Dosing Cohort	—	COMPLETED	2025-05-12	NCT06747247
AstraZeneca	Balcinrenone/dapagliflozin 15 mg/10 mg and matching placebo for dapagliflozin 10 mg	—	COMPLETED	2025-05-09	NCT06350123
Bayer	Finerenone (BAY94-8862 ) 10 mg	—	COMPLETED	2025-03-14	NCT05254002
Tourmaline Bio, Inc.	TOUR006 - 50 MG	—	COMPLETED	2025-03-06	NCT06362759
Shandong Suncadia Medicine Co., Ltd.	HRS-1780 tablet；Henagliflozin Proline tablet；HRS-1780 tablet placebo ；Henagliflozin Proline tablet placebo	—	COMPLETED	2025-03-05	NCT06221059
Mineralys Therapeutics Inc.	Lorundrostat 25mg+SGLT2i QD, Washout, Placebo+SGLT2i QD	—	COMPLETED	2025-02-27	NCT06150924
Shanghai Pharmaceuticals Holding Co., Ltd	SPH3127+SPH3127matching placebo+valsartan matching placebo	—	COMPLETED	2024-12-31	NCT05593575
Ebima Clifford Okundaye	QRX-3	—	COMPLETED	2024-08-30	NCT06948292
Inversago Pharma Inc.	INV-202	—	COMPLETED	2024-08-20	NCT05514548
Unicycive Therapeutics, Inc	Oxylanthanum Carbonate	—	COMPLETED	2024-05-29	NCT06218290
AstraZeneca	CIN-107	—	COMPLETED	2024-05-02	NCT05432167
MC2 Therapeutics	MC2-25 cream	—	COMPLETED	2024-02-02	NCT05482698
Prokidney	Renal Autologous Cell Therapy (REACT)	—	COMPLETED	2023-12	NCT02836574
Neurocrine UK Limited	Chronocort	—	COMPLETED	2023-10-18	NCT05222152
AstraZeneca	AZD9977	—	COMPLETED	2023-09-22	NCT04595370
Alebund Pharmaceuticals	AP-306	—	COMPLETED	2023-08-25	NCT05764590
Boehringer Ingelheim	Avenciguat	—	COMPLETED	2023-08-15	NCT04736628
AstraZeneca	Zibotentan	—	COMPLETED	2023-06-01	NCT04724837
AstraZeneca	MEDI3506	—	COMPLETED	2023-05-16	NCT04170543
Prokidney	Renal Autologous Cell Therapy (REACT)	—	COMPLETED	2022-11-17	NCT03270956
CSL Behring	CSL346	—	COMPLETED	2022-10-24	NCT04419467
AstraZeneca	Cotadutide 100 micrograms	—	COMPLETED	2022-03-08	NCT04515849
Bayer	runcaciguat	—	COMPLETED	2022-03-08	NCT04507061
Allena Pharmaceuticals	ALLN-346	—	COMPLETED	2022-03-02	NCT04987242
Xiamen Amoytop Biotech Co., Ltd.	YPEG-rhEPO	—	COMPLETED	2022-01-05	NCT04885647
Bayer	Finerenone (Kerendia, BAY94-8862)	—	COMPLETED	2021-12-31	NCT05013008
AstraZeneca	Verinurad	—	COMPLETED	2021-11-22	NCT03990363
Biogen	Bardoxolone methyl oral capsule	—	COMPLETED	2021-10-20	NCT04702997
Gilead	SEL	—	COMPLETED	2021-09-03	NCT04026165
Novo Nordisk	Ziltivekimab	—	COMPLETED	2021-08-03	NCT04626505
Roche	Mircera	Erythropoietin Receptor	COMPLETED	2021-07-19	NCT03552393
Novartis	Nidufexor	—	COMPLETED	2021-05-03	NCT03804879
KBP Biosciences	KBP-5074 0.25 mg tablet	—	COMPLETED	2020-08-05	NCT03574363
Dimerix Bioscience Pty Ltd	Propagermanium	—	COMPLETED	2020-07-23	NCT03627715
Novo Nordisk	Ziltivekimab	—	COMPLETED	2020-06-26	NCT03926117
Akebia Therapeutics	Vadadustat	Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitor [EPC]	COMPLETED	2020-06-05	NCT03799627
Kyntra Bio	Roxadustat	—	COMPLETED	2019-12-12	NCT01630889
Cara Therapeutics, Inc.	CR845 0.25 mg Oral Tablet	—	COMPLETED	2019-10-24	NCT03617536
Bayer	Fulacimstat (BAY1142524)	—	COMPLETED	2019-10-02	NCT03412006
Teijin America, Inc.	TMX-049	—	COMPLETED	2019-05-07	NCT03449199
UnicoCell Biomed CO. LTD	ELIXCYTE	—	COMPLETED	2019-04-23	NCT02933827
Pieris Pharmaceuticals GmbH	PRS-080#022-DP	—	COMPLETED	2019-03-30	NCT03325621
MedImmune LLC	MEDI0382	—	COMPLETED	2019-02-04	NCT03550378
Takeda	Lanthanum Carbonate	—	COMPLETED	2018-11-16	NCT01696279
Novartis	LHW090	—	COMPLETED	2018-10-11	NCT02678000
Fresenius Kabi	Ketosteril®	—	COMPLETED	2018-04-27	NCT03077048
Akebia Therapeutics	Vadadustat	Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitor [EPC]	COMPLETED	2017-10-24	NCT03054350
Tanabe Pharma Corporation	MT-3995 Low	—	COMPLETED	2017-08	NCT02676401
Akebia Therapeutics	Vadadustat	Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitor [EPC]	COMPLETED	2017-07-04	NCT03054337
Genexine, Inc.	GX-E2	—	COMPLETED	2017-04-20	NCT02044653
Vascular Pharmaceuticals, Inc.	VPI-2690B low dose	—	COMPLETED	2017-03	NCT02251067
Bayer	Molidustat (BAY85-3934)	—	COMPLETED	2016-11-15	NCT02055482
Tanabe Pharma Corporation	MT-3995 Low	—	COMPLETED	2016-11	NCT02517320
Astellas Pharma Europe B.V.	ASP8232	—	COMPLETED	2016-10-26	NCT02358096
Bayer	Molidustat (BAY85-3934)	—	COMPLETED	2016-10-19	NCT02064426
Gilead	Selonsertib	—	COMPLETED	2016-07	NCT02177786
Aevi Genomic Medicine, LLC, a Cerecor company	MDGN201 TARGTEPO	—	COMPLETED	2016-06-30	NCT02117427
Daiichi Sankyo	CS-3150	—	COMPLETED	2016-06	NCT02345057
3-C Institute for Social Development	—	—	COMPLETED	2016-06	NCT02864641
Kyowa Kirin Co., Ltd.	RTA 402	—	COMPLETED	2016-05	NCT02316821
La Jolla Pharmaceutical Company	GCS-100	—	COMPLETED	2016-05	NCT02155673
Capricor Inc.	Cenderitide	—	COMPLETED	2016-03-31	NCT02603614
Mallinckrodt	Repository Corticotropin Injection	—	COMPLETED	2016-01	NCT01601236
Bayer	Molidustat (BAY 85-3934)	—	COMPLETED	2015-10-23	NCT01975818
Bayer	BAY85-3934	—	COMPLETED	2015-10-15	NCT02021409
Bayer	BAY85-3934	—	COMPLETED	2015-09-15	NCT02021370
Eli Lilly	LY3016859	—	COMPLETED	2015-08	NCT01774981
Tanabe Pharma Corporation	MT-3995	—	COMPLETED	2015-08	NCT02205372
Astellas Pharma Inc	ASP1517	—	COMPLETED	2015-07-06	NCT01964196
AstraZeneca	Eculizumab	Complement Inhibitor [EPC]	COMPLETED	2015-06-11	NCT01567085
Genzyme, a Sanofi Company	Sevelamer carbonate	—	COMPLETED	2015-06	NCT01574326
Ardelyx	AZD1722	—	COMPLETED	2015-03	NCT01847092
Hansa Biopharma AB	IdeS	—	COMPLETED	2015-02	NCT02224820
Concert Pharmaceuticals	CTP-499	—	COMPLETED	2015-01	NCT01487109

Showing 100 of 161 trials (top 100 by completion date — export for full list)

Sponsor	Asset	MoA	Status	Primary Completion	NCT
AstraZeneca	AZD4248	—	RECRUITING	2026-06-18	NCT07024823
Beijing Continent Pharmaceutical Co, Ltd.	Hydronidone capsules	—	RECRUITING	2026-07-01	NCT07262333
Eli Lilly	LY3841136	—	RECRUITING	2026-10	NCT07426380
Mediar Therapeutics	MTX-439	—	RECRUITING	2027-05	NCT07473323
Novartis	OJR520	—	RECRUITING	2028-01-21	NCT07235059
Alebund Pharmaceuticals	AP303 150μg	—	RECRUITING	2025-09-25	NCT06666283
Henan Genuine Biotech Co., Ltd.	Azvudine tablets	—	RECRUITING	2025-08-30	NCT07001436
Consun Pharmaceutical Group	SK-08	—	RECRUITING	2025-08-07	NCT07021157
Shandong Suncadia Medicine Co., Ltd.	[14C]HRS-1780	—	NOT YET RECRUITING	2026-06	NCT07557407
Klotho Sciences Australia Pty Ltd.	Part 1 KS101	—	NOT YET RECRUITING	2026-04-01	NCT07143331
R3 Stem Cell	Amniotic and Umbilical Cord Tissue Procedure	—	NOT YET RECRUITING	2024-03-20	NCT03899298
Eli Lilly	LY3537031	—	COMPLETED	2026-04-16	NCT07165015
Eli Lilly	LY3537982	—	COMPLETED	2026-04-10	NCT07137689
Bayer	BAY3283142	—	COMPLETED	2025-11-21	NCT06428825
Novo Nordisk	NNC0705-0001	—	COMPLETED	2025-11-04	NCT07029568
AstraZeneca	AZD4144	—	COMPLETED	2025-10-27	NCT06675175
Disc Medicine, Inc	DISC-0974	—	COMPLETED	2025-10-09	NCT05745883
Bayer	BAY3283142	—	COMPLETED	2025-02-24	NCT06402721
Biocodex	STIRIPENTOL oral administration	—	COMPLETED	2024-11-30	NCT05735951
Bayer	BAY3283142	—	COMPLETED	2024-09-19	NCT06487845
Eli Lilly	LY3473329	—	COMPLETED	2024-09-06	NCT05778864
Novo Nordisk	Ziltivekimab	—	COMPLETED	2024-06-12	NCT05379829
Eli Lilly	LY3502970	—	COMPLETED	2024-04-11	NCT05936138
AdAlta Limited	AD-214	—	COMPLETED	2024-02-09	NCT05914909
Incyte Corporation	INCB054707	—	COMPLETED	2024-02-07	NCT05624723
Eli Lilly	LY3819469	—	COMPLETED	2024-01-09	NCT05841277
Haisco Pharmaceutical Group Co., Ltd.	HSK21542 Injection	—	COMPLETED	2023-11-21	NCT06238388
Boehringer Ingelheim	BI 425809	—	COMPLETED	2023-10-24	NCT05718843
Pharmicell Co., Ltd.	Cellgram-CKD	—	COMPLETED	2023-09-21	NCT05042206
Eli Lilly	LY3437943	—	COMPLETED	2023-09-05	NCT05611957
Sunshine Lake Pharma Co., Ltd.	HEC53856	—	COMPLETED	2023-08-29	NCT04925661
Boehringer Ingelheim	BI 1015550	—	COMPLETED	2023-08-15	NCT05718648
Bayer	BAY3283142	—	COMPLETED	2023-07-19	NCT05800444
Incyte Corporation	INCB054707	—	COMPLETED	2023-06-30	NCT05624710
Bayer	Single oral dose of BAY3283142 IR (immediate release) tablet	—	COMPLETED	2023-03-07	NCT05515432
Prokidney	Renal Autologous Cell Therapy (REACT)	—	COMPLETED	2023-01-31	NCT04115345
Lisata Therapeutics, Inc.	CLBS201	—	COMPLETED	2023-01-26	NCT04990427
Bristol-Myers Squibb	Iberdomide	—	COMPLETED	2023-01-23	NCT04933747
Sunshine Lake Pharma Co., Ltd.	HEC73077 tablets	—	COMPLETED	2023-01-04	NCT05492630
Bayer	BAY3283142	—	COMPLETED	2023-01-03	NCT05491642
Nanogen Pharmaceutical Biotechnology Joint Stock Company	Stimus	—	COMPLETED	2022-11-23	NCT05636891
AstraZeneca	cotadutide solution for injection	—	COMPLETED	2022-09-12	NCT05294458
AN2 Therapeutics, Inc	Epetraborole	—	COMPLETED	2022-06-10	NCT05283746
Zydus Lifesciences Limited	Desidustat	—	COMPLETED	2022-03-27	NCT04667533
AstraZeneca	Zibotentan (Treatment A)	—	COMPLETED	2021-10-22	NCT04991571
Pfizer	Aztreonam-Avibactam	—	COMPLETED	2021-09-20	NCT04486625
AstraZeneca	Verinurad prolonged release HPMC capsule	—	COMPLETED	2021-07-15	NCT04550234
VectivBio AG	Apraglutide	—	COMPLETED	2021-07-05	NCT04699032
Eli Lilly	Pirtobrutinib	Kinase Inhibitor [EPC]	COMPLETED	2021-06-04	NCT06190678
Jiangsu HengRui Medicine Co., Ltd.	DDO-3055	—	COMPLETED	2021-05-11	NCT03976115
Rhythm Pharmaceuticals, Inc.	Setmelanotide	—	COMPLETED	2021-04-17	NCT04348175
AstraZeneca	AZD5718	—	COMPLETED	2021-03-25	NCT04734275
Takeda	Azacitidine	Nucleoside Metabolic Inhibitor [EPC]	COMPLETED	2021-03-19	NCT03814005
AstraZeneca	MEDI8367	—	COMPLETED	2021-01-03	NCT04365218
AstraZeneca	Verinurad	—	COMPLETED	2020-11-23	NCT04532918
Boehringer Ingelheim	BI 764198	—	COMPLETED	2020-11-17	NCT04176536
Idorsia Pharmaceuticals Ltd.	ACT-541468	—	COMPLETED	2020-08-14	NCT04024332
Renibus Therapeutics, Inc.	RBT-9	—	COMPLETED	2020-07-31	NCT04072861
Akebia Therapeutics	Vadadustat	Hypoxia-inducible Factor Prolyl Hydroxylase Inhibitor [EPC]	COMPLETED	2020-05-05	NCT03992066
Renibus Therapeutics, Inc.	RBT-1	—	COMPLETED	2020-04-22	NCT03893799
Ensoma	MGTA-145	—	COMPLETED	2020-03-24	NCT04154670
Genfit	Elafibranor	Peroxisome Proliferator-activated Receptor Agonist [EPC]	COMPLETED	2020-03-15	NCT03844555
Bayer	Copanlisib (ALIQOPA, BAY80-6946)	—	COMPLETED	2020-03-13	NCT03172884
Jiangsu HengRui Medicine Co., Ltd.	DDO-3055 tablet	—	COMPLETED	2020-01-18	NCT04197778
AstraZeneca	Verinurad ER8 capsule formulation (fasted)	—	COMPLETED	2019-09-18	NCT04024501
Eli Lilly	Tirzepatide	Glucose-dependent Insulinotropic Polypeptide Receptor Agonist [EPC]	COMPLETED	2019-08-19	NCT03482024
Eli Lilly	Selpercatinib	Kinase Inhibitor [EPC]	COMPLETED	2019-08-07	NCT05469100
DiaMedica Therapeutics Inc	DM199	—	COMPLETED	2019-07-21	NCT03795389
AstraZeneca	Verinurad	—	COMPLETED	2019-04-26	NCT03836599
Renibus Therapeutics, Inc.	RBT-3	—	COMPLETED	2019-03-31	NCT04072432
Guerbet	P03277	—	COMPLETED	2019-02-01	NCT03657784
Amgen	Etelcalcetide	CaSR	COMPLETED	2018-10-31	NCT02833857
Boehringer Ingelheim	BI 1467335	—	COMPLETED	2018-08-16	NCT03302091
Novartis	QAW039	—	COMPLETED	2018-08-07	NCT03087942
Merck	Midazolam oral solution	—	COMPLETED	2018-08-02	NCT03311841
MedImmune LLC	MEDI0382	—	COMPLETED	2018-04-24	NCT03235375
Johnson & Johnson	Odalasvir	—	COMPLETED	2018-04-09	NCT02961660
Bristol-Myers Squibb	CC-122	—	COMPLETED	2017-12-23	NCT03097016
Janssen Pharmaceutica N.V., Belgium	JNJ-64041575	—	COMPLETED	2017-12-06	NCT03189498
Merck	Gefapixant	—	COMPLETED	2017-09-03	NCT03108924
Johnson & Johnson	AL-335	—	COMPLETED	2017-08-08	NCT02894905
Sarfez Pharmaceuticals, Inc.	Demadex 20mg Tablet	—	COMPLETED	2017-07-20	NCT03214874
Taisho Pharmaceutical Co., Ltd.	TS-143	—	COMPLETED	2017-07-06	NCT03581071
Rockwell Medical Technologies, Inc.	Triferic	—	COMPLETED	2017-07	NCT02909153
Bayer	BAY1841788	—	COMPLETED	2017-04-10	NCT02894385
KBP Biosciences	KBP-5074	—	COMPLETED	2016-12-20	NCT02837237
Akros Pharma Inc.	JTZ-951, 14C-JTZ-951	—	COMPLETED	2016-09	NCT02805244
Eli Lilly	LY3113593	—	COMPLETED	2016-06-22	NCT02604160
KBP Biosciences	KBP-5074	—	COMPLETED	2016-05-26	NCT02653014
Akros Pharma Inc.	JTZ-951	—	COMPLETED	2016-04	NCT02581124
Gilead	Selonsertib	—	COMPLETED	2015-12-15	NCT02509624
Bayer	Molidustat(BAY85-3934)	—	COMPLETED	2015-12-02	NCT02312973
Prolong Pharmaceuticals	SANGUINATE	—	COMPLETED	2015-11-18	NCT02437422
Eli Lilly	LY2928057	—	COMPLETED	2015-10	NCT01991483
Amgen	Cinacalcet	—	COMPLETED	2015-09-23	NCT01290029
Intarcia Therapeutics	ITCA 650 (Exenatide in osmotic mini pump)	—	COMPLETED	2015-07	NCT02320045
Fuji Yakuhin Co., Ltd.	FYU-981, (Oral single dosing)	—	COMPLETED	2015-03	NCT02347046
Jiangsu HengRui Medicine Co., Ltd.	SP2086	—	COMPLETED	2015-01	NCT02815774
Boehringer Ingelheim	Afatinib healthy	—	COMPLETED	2014-12	NCT02096718
Astellas Pharma Inc	ASP3325	—	COMPLETED	2014-11-04	NCT02510274

Novel Drugs by Company (New molecular entities)

KAI PHARMS INC 1 drug

PARSABIV

ETELCALCETIDE

NDA 2017

LEXICON PHARMS INC 1 drug

Amgen 1 drug

HOFFMAN-LA ROCHE 1 drug

MIRCERA

METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA

BLA 2007

VIFOR INTL 1 drug

KORSUVA

DIFELIKEFALIN ACETATE

AKEBIA 1 drug

Reformulations (17 drugs) Click to expand

Reformulations are FDA-approved versions of existing molecules in new dosage forms (e.g., oral solution vs tablet, extended-release vs immediate-release). They require a new NDA but use an already-proven active ingredient.