TNF-alpha
20 drugsTumor Necrosis Factor Alpha
Predictive biomarker for patient selection in 23 indications
Understanding TNF-alpha
What it means: TNF-alpha is a key inflammatory cytokine produced by macrophages. Drives inflammation in rheumatoid arthritis, IBD, and psoriasis.
Why it matters: Anti-TNF biologics (Humira, Remicade, Enbrel) are among the most successful drugs ever, controlling autoimmune inflammation.
Testing: Not routinely tested. Anti-TNF drugs selected based on diagnosis. TB screening required before starting treatment.
20
Approved Drugs
23
Indications
14
Companies
TNF-alpha is a precision-medicine biomarker linked to 20 FDA-approved targeted drugs from 14 companies, spanning 23 indications including Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis. Explore the targeted therapies, indications, testing methods, and companies developing TNF-alpha drugs below.
Search TNF-alpha Clinical Trials
Search recruiting trials on ClinicalTrials.gov
Drugs Targeting TNF-alpha
| Drug | Company | Therapeutic Area |
|---|---|---|
| ABRILADA | Pfizer | Immunology |
| AMJEVITA | Amgen | Immunology |
| AVSOLA | Amgen | Immunology |
| CIMZIA | UCB INC | Immunology |
| CYLTEZO | Boehringer Ingelheim | Immunology |
| ENBREL | IMMUNEX | Immunology |
| HADLIMA | SAMSUNG BIOEPIS CO LTD | Immunology |
| HULIO | Viatris | Immunology |
| HUMIRA | AbbVie | Immunology |
| HYRIMOZ | Novartis | Immunology |
| IDACIO | Fresenius Kabi | Immunology |
| INFLECTRA | CELLTRION | Immunology |
| REMICADE | Johnson & Johnson | Immunology |
| RENFLEXIS | SAMSUNG BIOEPIS CO LTD | Immunology |
| SIMLANDI | ALVOTECH USA INC | Immunology |
| SIMPONI | Johnson & Johnson | Immunology |
| SIMPONI ARIA | Johnson & Johnson | Immunology |
| YUFLYMA | CELLTRION | Immunology |
| YUSIMRY | COHERUS BIOSCIENCES INC | Immunology |
| ZYMFENTRA | CELLTRION | Immunology |
TNF-alpha Indications
Rheumatoid Arthritis Psoriatic Arthritis Ankylosing Spondylitis Juvenile Idiopathic Arthritis Ulcerative Colitis Crohn's Disease Rheumatoid arthritis Psoriatic arthritis Ankylosing spondylitis Ulcerative colitis Crohn’s Disease Plaque Psoriasis Hidradenitis Suppurativa Chronic Plaque Psoriasis Uveitis Pediatric Crohn's Disease Pediatric Ulcerative Colitis Polyarticular Juvenile Idiopathic Arthritis Juvenile Psoriatic Arthritis Fistulizing Disease Crohn Disease Axial Spondyloarthritis Fistula