TNF-alpha
20 drugsTumor Necrosis Factor Alpha
Predictive biomarker for patient selection in 23 indications
Understanding TNF-alpha
What it means: TNF-alpha is a key inflammatory cytokine produced by macrophages. Drives inflammation in rheumatoid arthritis, IBD, and psoriasis.
Why it matters: Anti-TNF biologics (Humira, Remicade, Enbrel) are among the most successful drugs ever, controlling autoimmune inflammation.
Testing: Not routinely tested. Anti-TNF drugs selected based on diagnosis. TB screening required before starting treatment.
20
Approved Drugs
23
Indications
14
Companies
TNF-alpha is a precision-medicine biomarker linked to 20 FDA-approved targeted drugs from 14 companies, spanning 23 indications including Rheumatoid Arthritis, Juvenile Idiopathic Arthritis, Psoriatic Arthritis. Explore the targeted therapies, indications, testing methods, and companies developing TNF-alpha drugs below.
Search TNF-alpha Clinical Trials
Search recruiting trials on ClinicalTrials.gov
Drugs Targeting TNF-alpha
| Drug | Company | Therapeutic Area |
|---|---|---|
| ABRILADA | Pfizer | Immunology |
| AMJEVITA | Amgen | Immunology |
| AVSOLA | Amgen | Immunology |
| CIMZIA | UCB INC | Immunology |
| CYLTEZO | Boehringer Ingelheim | Immunology |
| ENBREL | IMMUNEX | Immunology |
| HADLIMA | SAMSUNG BIOEPIS CO LTD | Immunology |
| HULIO | Viatris | Immunology |
| HUMIRA | AbbVie | Immunology |
| HYRIMOZ | Novartis | Immunology |
| IDACIO | Fresenius Kabi | Immunology |
| INFLECTRA | CELLTRION INC | Immunology |
| REMICADE | Johnson & Johnson | Immunology |
| RENFLEXIS | SAMSUNG BIOEPIS CO LTD | Immunology |
| SIMLANDI | ALVOTECH USA INC | Immunology |
| SIMPONI | Johnson & Johnson | Immunology |
| SIMPONI ARIA | Johnson & Johnson | Immunology |
| YUFLYMA | CELLTRION INC | Immunology |
| YUSIMRY | EMERGE BIOSCIENCE PTE LTD | Immunology |
| ZYMFENTRA | CELLTRION INC | Immunology |
TNF-alpha Indications
Rheumatoid Arthritis Juvenile Idiopathic Arthritis Psoriatic Arthritis Ankylosing Spondylitis Crohn's Disease Ulcerative Colitis Chronic Plaque Psoriasis Hidradenitis Suppurativa Uveitis Crohn’s Disease Plaque Psoriasis Polyarticular Juvenile Idiopathic Arthritis Juvenile Psoriatic Arthritis Axial Spondyloarthritis Fistulizing Disease Pediatric Crohn's Disease Pediatric Ulcerative Colitis Rheumatoid arthritis Psoriatic arthritis Ankylosing spondylitis Ulcerative colitis Crohn Disease Fistula