TheraRadar
Data updated: May 26, 2026

FLYRCADO (flurpiridaz f-18)

Positron Emitting Activity
Cardiovascular Approved 2024-09-27

Flyrcado is a radioactive diagnostic agent used for PET imaging of the heart in adults who have or are suspected of having coronary artery disease. It helps clinicians evaluate blood flow to the heart muscle during both resting and active states, such as exercise or pharmacologic stress. By using this imaging tool, healthcare providers can identify areas of the heart experiencing reduced blood flow or permanent damage from a previous heart attack.

Source: FDA Label • GE HLTHCARE • Radioactive Diagnostic Agent

How FLYRCADO Works

This agent works by binding to mitochondrial complex 1 within heart tissue that contains active mitochondria. The drug is absorbed by the heart muscle in proportion to the amount of blood flow it receives. This allows for a clear distinction in radioactivity levels between healthy, viable heart tissue and areas that have been infarcted.

1
Indication
--
Phase 3 Trials
1
Years on Market

Details

Status
Prescription
First Approved
2024-09-27
Patent Cliff
2042

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Routes
INTRAVENOUS
Dosage Forms
SOLUTION

Companies

Active Ingredient: FLURPIRIDAZ F-18

FLYRCADO Approval History

2025
2026
Original
New Indication
New Form
Label Update
1 FDA actions from 2024 to 2024
Sep 2024 ORIGINAL
New Drug · Type 1 - New Molecular Entity

What FLYRCADO Treats

3 indications

FLYRCADO is approved for 3 conditions since its original approval in 2024. These indications span multiple therapeutic areas including oncology, immunology, and more.

  • Coronary Artery Disease
  • Myocardial Ischemia
  • Myocardial Infarction
Source: FDA Label

FLYRCADO Competitive Set

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Filters applied: drops same-active-ingredient (505(b)(2) reformulations), route-mismatch (topical vs systemic), and cross-therapeutic-area matches in same-indication rings.

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Active Pipeline

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Key Completed Trials

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Trial Timeline

Full development history with FDA approval milestones

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Understanding FDA Approval Types
Count Type What it means
- ORIG Original approval - drug first enters market
- SUPPL - Efficacy New indication (new disease/condition approved)
- SUPPL - Labeling Label text changes (warnings, dosing updates)
- SUPPL - Manufacturing Production changes (new facility)
- SUPPL - Chemistry Formulation changes (new dosage strength)

Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.

FLYRCADO FDA Label Details

Indications & Usage

FDA Label (PDF)

FLYRCADO is indicated for the treatment of Coronary Artery Disease; Myocardial Ischemia; Myocardial Infarction.

View full patent landscape →
7 OB patents · 4 families · 187 international docs across 24 countries

FLYRCADO Patents & Exclusivity

Latest Patent: May 2042
Exclusivity: Sep 2029

Patents (7 active)

US12527884 Expires May 13, 2042
US9687571 Expires Nov 1, 2032
US8936777 Expires Jun 30, 2031
US9603951 Expires May 2, 2031
US8226929 Expires Jun 21, 2028
US7344702 Expires May 26, 2026
US9161997 Expires Feb 4, 2026

Exclusivity

NCE Until Sep 2029
Source: FDA Orange Book

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Patent Timeline

  • Cliff: 2042
  • 7 active patents

Trial Analysis

  • Clinical trial tracking
  • Development stage analysis

Competitive Landscape

  • 20 similar drugs
  • Same target/indication analysis
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Data Sources

Data sourced from official FDA and NIH databases. Click links to verify on original sources.