HEMICLOR (chlorthalidone)
Hemiclor is a thiazide-like diuretic used to lower blood pressure in adults with hypertension. By managing high blood pressure, this medication helps patients reduce their risk of serious cardiovascular events, including strokes and heart attacks. It is often used as one part of a comprehensive management plan that includes lifestyle changes and other medications to control cardiovascular risk.
Details
- Status
- Prescription
- First Approved
- 2025-03-17
- Routes
- ORAL
- Dosage Forms
- TABLET
HEMICLOR Approval History
What HEMICLOR Treats
1 indicationsHEMICLOR is approved for 1 conditions since its original approval in 2025. These indications span multiple therapeutic areas including oncology, immunology, and more.
- Hypertension
HEMICLOR Competitive Set
ProThree rings of competition based on shared molecular targets and treated indications.
Indication competitors
Same indication, different mechanism — what else might this patient receive?
Filters applied: drops same-active-ingredient (505(b)(2) reformulations), route-mismatch (topical vs systemic), and cross-therapeutic-area matches in same-indication rings.
What's emerging in HEMICLOR's indications
See all emerging drugs →Phase 3 candidates targeting molecules with no FDA-approved drug, in indications HEMICLOR treats. First-in-class if their pivotal trials read out positive.
Drugs Similar to HEMICLOR
3 of 20FDA-approved drugs for similar conditions. Compare mechanisms and indications to understand treatment alternatives.
Clinical Trial Registry
17 trials| Trial | Sponsor ID | Phase | Status | Title |
|---|---|---|---|---|
| NCT05915286 DIURESED | Pro00119451 | Ph 4 | terminated | Diuretic Use in Hemodialysis Patients With Residual Renal Function |
| NCT05593055 | 2022P002126 | Ph 4 | recruiting | Mineralocorticoid Receptor, Coronary Microvascular Function, and Cardiac Efficiency in Hypertension |
| NCT07225764 | STUDY-25-00784 | Ph 4 | recruiting | CaOx Stone Prevention |
| NCT05275907 | STU00215781 1R56HL155093-01 | Ph 4 | withdrawn | Mechanism of Hypertension Treatments in Liver Transplant Recipients (BLOCK LTR-HTN) |
| NCT02841280 CLICK results posted | 1507540384 | Ph 2 | completed | Chlorthalidone in Chronic Kidney Disease |
| NCT04757532 ESPAMA | IMIMFTCL/ESPAMA | Ph 1 | completed | Study of Exposure to Substances Prohibited by the World Anti-Doping Agency in Healthy Volunteers. |
| NCT03325114 results posted | 66282 1K23DK114477-01 | Ph 2 | terminated | Safety and Efficacy of Chlorthalidone in Type 1 Diabetes |
| NCT03923933 results posted | DI/19/105-B/03/018 | Ph 2 | completed | Chlortalidone and Bumetanide in Advanced Chronic Kidney Disease: HEBE-CKD Trial |
| NCT02236520 results posted | 141382 | Ph 2 | completed | Tissue Sodium in Pre-hypertensive Patients |
| NCT01203852 PEAR2 results posted | IRB201700661-N U01GM074492-06 | Ph 4 | completed | Pharmacogenomic Evaluation of Antihypertensive Responses 2 |
| NCT01748123 | PCORI-EGID 4231 00041242 | Ph 4 | withdrawn | EBMtrialcentral- Comparing Initial Diuretic Therapies Using a Collaborative Network |
| NCT02644395 TT | MEC-2012-417 | Ph 3 | completed | Thiazide Diuretics for Hypertension in Kidney Transplant Recipients Using Tacrolimus |
| NCT02030314 | HM20002960 | Ph 4 | withdrawn | The Management of Resistant Hypertension in Kidney Transplant Patients Using Chlorthalidone |
| NCT01750294 results posted | 1206009002 1206009002 | Ph 4 | completed | A Pilot Study of Chlorthalidone Among Patients With Poorly Controlled Hypertension and CKD |
| NCT02152969 | YH22162-101 | Ph 1 | completed | Drug-drug Interaction Study (Telmisartan, Amlodipine, Chlorthalidone) |
| NCT01368536 VALENCIA results posted | CSPV100AUS05 | Ph 4 | terminated | Study to Evaluate the Efficacy and Safety of the Combination of Valturna and Amlodipine or Valturna and Chlorthalidone Versus Valturna Alone in Patients With Stage 2 Hypertension and Diabetes |
| NCT00847626 results posted | TAK-491CLD_302 2008-004218-28, U1111-1113-8735 | Ph 3 | completed | Efficacy and Safety of Azilsartan Medoxomil Combined With Chlorthalidone in Participants With Moderate to Severe Hypertension |
Active Pipeline
Ongoing clinical trials by development phase
Key Completed Trials
Completed studies with published results, ranked by significance
Trial Timeline
Full development history with FDA approval milestones
Understanding FDA Approval Types
| Count | Type | What it means |
|---|---|---|
| - | ORIG | Original approval - drug first enters market |
| - | SUPPL - Efficacy | New indication (new disease/condition approved) |
| - | SUPPL - Labeling | Label text changes (warnings, dosing updates) |
| - | SUPPL - Manufacturing | Production changes (new facility) |
| - | SUPPL - Chemistry | Formulation changes (new dosage strength) |
Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.
HEMICLOR FDA Label Details
Indications & Usage
FDA Label (PDF)HEMICLOR is indicated for the treatment of Hypertension.
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Data Sources
Data sourced from official FDA and NIH databases. Click links to verify on original sources.