STARJEMZA (ustekinumab-hmny)
STARJEMZA is indicated for the treatment of Plaque Psoriasis; Psoriatic Arthritis; Crohn’s Disease; Ulcerative Colitis.
How STARJEMZA Works
STARJEMZA is a monoclonal antibody that binds specifically to the p40 protein subunit shared by the IL-12 and IL-23 cytokines. By targeting this subunit, the drug prevents these cytokines from interacting with the IL-12Rβ1 cell-surface receptor. This disruption inhibits the signaling and cytokine cascades that drive inflammatory and immune responses, including natural killer cell activation and T-cell differentiation. This mechanism is designed to reduce the chronic inflammation that characterizes diseases such as Crohn’s disease and ulcerative colitis.
Details
- Status
- Prescription
- First Approved
- 2025-05-22
- Routes
- SUBCUTANEOUS
- Dosage Forms
- INJECTABLE
STARJEMZA Approval History
What STARJEMZA Treats
4 indicationsSTARJEMZA is approved for 4 conditions since its original approval in 2025. These indications span multiple therapeutic areas including oncology, immunology, and more.
- Plaque Psoriasis
- Psoriatic Arthritis
- Crohn’s Disease
- Ulcerative Colitis
STARJEMZA Target & Pathway
ProTarget
Pharmacists can substitute STARJEMZA for Stelara without calling the prescriber. This is a lower-cost alternative with no clinically meaningful differences.
STARJEMZA Competitive Set
ProThree rings of competition based on shared molecular targets and treated indications.
Direct competitors
Same target(s) AND same indication — head-to-head.
Indication competitors
Same indication, different mechanism — what else might this patient receive?
Filters applied: drops same-active-ingredient (505(b)(2) reformulations), route-mismatch (topical vs systemic), and cross-therapeutic-area matches in same-indication rings.
What's emerging in STARJEMZA's indications
See all emerging drugs →Phase 3 candidates targeting molecules with no FDA-approved drug, in indications STARJEMZA treats. First-in-class if their pivotal trials read out positive.
Drugs Similar to STARJEMZA
3 of 20FDA-approved drugs for similar conditions. Compare mechanisms and indications to understand treatment alternatives.
Active Pipeline
Ongoing clinical trials by development phase
Key Completed Trials
Completed studies with published results, ranked by significance
Trial Timeline
Full development history with FDA approval milestones
Understanding FDA Approval Types
| Count | Type | What it means |
|---|---|---|
| - | ORIG | Original approval - drug first enters market |
| - | SUPPL - Efficacy | New indication (new disease/condition approved) |
| - | SUPPL - Labeling | Label text changes (warnings, dosing updates) |
| - | SUPPL - Manufacturing | Production changes (new facility) |
| - | SUPPL - Chemistry | Formulation changes (new dosage strength) |
Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.
STARJEMZA FDA Label Details
Indications & Usage
FDA Label (PDF)STARJEMZA is indicated for the treatment of Plaque Psoriasis; Psoriatic Arthritis; Crohn’s Disease; Ulcerative Colitis.
Explore on TheraRadar
Crohn's Disease Drug Landscape 2026
Approved therapies, pipeline drugs, and clinical trial intelligence
Related Intelligence
Data Sources
Data sourced from official FDA and NIH databases. Click links to verify on original sources.