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Type 2 Diabetes

Metabolic 6 original drugs
6
Novel Drugs
33
Reformulations
280
Active Trials
22
Drug Targets

Phase 3 Readouts Pro

12 active Phase 3 trials with confidence-graded completion dates.

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Q2 2026
Retatrutide
Eli Lilly
Estimated · fresh NCT05929079
Q2 2026
LID104
EMS
Estimated · stale NCT05886088
Q2 2026
CT-L03 Group 1
Celltrion
Estimated · fresh NCT06571591
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Anchored on CT.gov primary completion date. Topline announcements typically precede this by 3–9 months. Confidence labels combine date type (ACTUAL/ESTIMATED) with last-update freshness.

Treatments by Mechanism

Top 12 mechanisms across 341 industry trials with a known mechanism of action.

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Glucose-dependent Insulinotropic Polypeptide Receptor Agonist
29 trials 7 active 2 sponsors
GLP-1 Receptor Agonist
107 trials 3 active 3 sponsors
Insulin Analog
58 trials 4 sponsors
SGLT2
54 trials 6 sponsors
Dipeptidyl Peptidase 4 Inhibitor
37 trials 3 sponsors
Sodium-Glucose Cotransporter 2 Inhibitor
24 trials 5 sponsors
DPP-4
9 trials 2 sponsors
Anti-anginal
7 trials 1 sponsor
Sulfonylurea
6 trials 4 sponsors
DPP-4/SGLT2
6 trials 1 sponsor
HMG-CoA Reductase Inhibitor
3 trials 3 sponsors
Glinide
1 trials 1 sponsor

MoA derived from FDA pharmClassEpc when intervention matches an approved drug. Codenamed clinical-stage assets without an approved counterpart show "—" and aren't grouped here — they're still in the phase tables below.

Clinical Pipeline by Phase

1906 industry-sponsored trials across 278 sponsors

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Precision Medicine Biomarkers

All biomarkers →

Biomarkers used for patient selection in Type 2 Diabetes

Reformulations (33 drugs) Click to expand
Generic Drugs (12 ANDA approved) Click to expand

Related Indications

Other Metabolic indications

Drug Categories:

  • Novel Drugs: NDA Type 1/2 (new molecular entity) or original BLA
  • Reformulations: NDA Type 3/5 (new dosage form of existing molecule)
  • Biosimilars: BLA-approved biologics highly similar to reference products
  • Generics: ANDA-approved copies of small molecule drugs

View data sources and methodology