ALOPRIM (allopurinol sodium)
Aloprim helps adult and pediatric cancer patients manage high levels of uric acid in their blood and urine caused by certain cancer therapies. It is used for individuals with leukemia, lymphoma, or solid tumors who are unable to take oral medications. By controlling these uric acid levels, the drug helps prevent complications that can arise during intensive cancer treatment.
How ALOPRIM Works
Aloprim works by blocking xanthine oxidase, the specific enzyme responsible for converting purine bases into uric acid. By inhibiting this process, the medication reduces the overall production of uric acid in both the blood and urine. This approach avoids the risks associated with drugs that lower uric acid by forcing the kidneys to excrete more of it.
Details
- Status
- Prescription
- First Approved
- 1996-05-17
- Routes
- INJECTION
- Dosage Forms
- INJECTABLE
ALOPRIM Approval History
What ALOPRIM Treats
3 indicationsALOPRIM is approved for 3 conditions since its original approval in 1996. These indications span multiple therapeutic areas including oncology, immunology, and more.
- Leukemia
- Lymphoma
- Solid Tumor Malignancies
ALOPRIM Competitive Set
ProThree rings of competition based on shared molecular targets and treated indications.
Direct competitors
Same target(s) AND same indication — head-to-head.
MoA expansion candidates
Same target(s), different indications — where else is this mechanism being explored?
Indication competitors
Same indication, different mechanism — what else might this patient receive?
Filters applied: drops same-active-ingredient (505(b)(2) reformulations), route-mismatch (topical vs systemic), and cross-therapeutic-area matches in same-indication rings.
What's emerging in ALOPRIM's indications
See all emerging drugs →Phase 3 candidates targeting molecules with no FDA-approved drug, in indications ALOPRIM treats. First-in-class if their pivotal trials read out positive.
Drugs Similar to ALOPRIM
3 of 9FDA-approved drugs for similar conditions. Compare mechanisms and indications to understand treatment alternatives.
Active Pipeline
Ongoing clinical trials by development phase
Key Completed Trials
Completed studies with published results, ranked by significance
Trial Timeline
Full development history with FDA approval milestones
Understanding FDA Approval Types
| Count | Type | What it means |
|---|---|---|
| - | ORIG | Original approval - drug first enters market |
| - | SUPPL - Efficacy | New indication (new disease/condition approved) |
| - | SUPPL - Labeling | Label text changes (warnings, dosing updates) |
| - | SUPPL - Manufacturing | Production changes (new facility) |
| - | SUPPL - Chemistry | Formulation changes (new dosage strength) |
Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.
ALOPRIM FDA Label Details
Indications & Usage
FDA Label (PDF)ALOPRIM is indicated for the treatment of Leukemia; Lymphoma; Solid Tumor Malignancies.
Track ALOPRIM with TheraRadar Pro
Watchlist alerts, full database access, CSV exports across 14,000+ drugs.
Data Sources
Data sourced from official FDA and NIH databases. Click links to verify on original sources.