VASOPRESSIN IN DEXTROSE 5% (vasopressin)
Vasopressin in Dextrose 5% is used for adults experiencing vasodilatory shock. It helps patients with dangerously low blood pressure who have not responded adequately to initial treatments like fluids and catecholamines. This medication works by increasing blood pressure to help stabilize patients in these critical situations.
How VASOPRESSIN IN DEXTROSE 5% Works
This medication works by binding to V1 receptors on vascular smooth muscle, which triggers a pathway that releases intracellular calcium and causes the blood vessels to constrict. Additionally, it stimulates V2 receptors to promote antidiuresis. These actions together help increase the patient's blood pressure.
Details
- Status
- Prescription
- First Approved
- 2024-02-09
- Routes
- INTRAVENOUS
- Dosage Forms
- SOLUTION
VASOPRESSIN IN DEXTROSE 5% Approval History
What VASOPRESSIN IN DEXTROSE 5% Treats
2 indicationsVASOPRESSIN IN DEXTROSE 5% is approved for 2 conditions since its original approval in 2024. These indications span multiple therapeutic areas including oncology, immunology, and more.
- Vasodilatory Shock
- Hypotension
VASOPRESSIN IN DEXTROSE 5% Competitive Set
ProThree rings of competition based on shared molecular targets and treated indications.
MoA expansion candidates
Same target(s), different indications — where else is this mechanism being explored?
Indication competitors
Same indication, different mechanism — what else might this patient receive?
Filters applied: drops same-active-ingredient (505(b)(2) reformulations), route-mismatch (topical vs systemic), and cross-therapeutic-area matches in same-indication rings.
Drugs Similar to VASOPRESSIN IN DEXTROSE 5%
3 of 16FDA-approved drugs for similar conditions. Compare mechanisms and indications to understand treatment alternatives.
Clinical Trial Registry
21 trials| Trial | Sponsor ID | Phase | Status | Title |
|---|---|---|---|---|
| NCT05958342 CAVALIER | STUDY23040043 W81XWH-6-D-0024 | Ph 2 | recruiting | CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial |
| NCT05738148 | Pro00122275 | Ph 1 | active not recruiting | Vasopressin vs. Epinephrine During Neonatal Cardiopulmonary Resuscitation |
| NCT02118467 | 14-0047 | Ph 4 | recruiting | Vasoactive Drugs in Intensive Care Unit |
| NCT05568160 NOVACC | GUINOT PHRCI 2019 | Ph 3 | active not recruiting | Evaluation of the Superiority of VAsopressin Versus NOradrenaline in the Management of Patients at Risk of Kidney Failure Undergoing Cardiac Surgery With Extracorporeal Circulation |
| NCT06217562 VASSPR | 1052518 | Ph 4 | active not recruiting | Vasopressin for Septic Shock Pragmatic Trial |
| NCT06547892 NOVA-AKI | NOVA-AKI | Ph 2 | recruiting | Use of Vasopressin in Patients at High Risk of Acute Kidney Injury Admitted to the ICU |
| NCT04501861 results posted | 20-301 | Ph 3 | completed | Hemodynamic Effect of Norepinephrine Versus Vasopressin on the Pulmonary Circulation in Cardiac Surgery Patients: |
| NCT06419075 TEXAS | 23-0273 | Ph 4 | withdrawn | Tranexamic Acid in Vaginal Reconstructive Surgery |
| NCT02975999 results posted | HRP-530 | Ph 2, Ph 3 | completed | Use of Vasopressin Following the Fontan Operation |
| NCT05193370 | 21-040 UL1TR001449 | Ph 4 | withdrawn | Angiotensin II vs. Vasopressin in Septic Shock |
| NCT03483753 VANCSIII | 62586316.6.0000.0065 | Ph 2, Ph 3 | withdrawn | Vasopressin or Norepinephrine in Vasoplegic Shock After Non-cardiac Surgery |
| NCT01093768 | 100068 10-M-0068 | Ph 1 | completed | Brain Imaging Study of Adults With Autism Spectrum Disorders |
| NCT00628550 Vasopressin | 082007-065 | Ph 1 | completed | Trial of Vasopressin and Epinephrine to Epinephrine Only for In-Hospital Pediatric Cardiopulmonary Resuscitation |
| NCT01962870 results posted | IRB-26034 R21MH100387-01 | Ph 2 | completed | The Role of Vasopressin in the Social Deficits of Autism |
| NCT01611935 AVERTShock results posted | 811293 | Ph 2 | completed | AVERT Shock: Arginine Vasopressin During the Early Resuscitation of Traumatic Shock |
| NCT03930069 | Hysterscopioc myomectomy | Ph 2, Ph 3 | completed | Vasopressin Injection Versus Misoprostol During Hysteroscopic Myomectomy In Reducing Blood Loss And Operation Time. |
| NCT01718613 VANCS II | NP 1079/17 | Ph 3 | completed | Vasopressin Versus Norepinephrine for the Management of Septic Shock in Cancer Patients |
| NCT01393704 results posted | 2011-P-000264/1 | Ph 4 | completed | Vasopressin Administration During Laparoscopic Myomectomy: a Randomized Controlled Trial |
| NCT02454348 NOVEL | 204265 | Ph 4 | withdrawn | NOrepinephrine and VasoprEssin Versus Norepinephrine aLone in Critically Ill Patients With Septic Shock |
| NCT01861015 | KNC13-013 | Ph 3 | completed | Vasopressin Versus Epinephrine in Myomectomy |
| NCT00379522 | Vitris | Ph 2, Ph 3 | completed | Vasopressin in Traumatic Hemorrhagic Shock Study |
Active Pipeline
Ongoing clinical trials by development phase
Key Completed Trials
Completed studies with published results, ranked by significance
Trial Timeline
Full development history with FDA approval milestones
Understanding FDA Approval Types
| Count | Type | What it means |
|---|---|---|
| - | ORIG | Original approval - drug first enters market |
| - | SUPPL - Efficacy | New indication (new disease/condition approved) |
| - | SUPPL - Labeling | Label text changes (warnings, dosing updates) |
| - | SUPPL - Manufacturing | Production changes (new facility) |
| - | SUPPL - Chemistry | Formulation changes (new dosage strength) |
Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.
VASOPRESSIN IN DEXTROSE 5% FDA Label Details
Indications & Usage
VASOPRESSIN IN DEXTROSE 5% is indicated for the treatment of Vasodilatory Shock; Hypotension.
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Data Sources
Data sourced from official FDA and NIH databases. Click links to verify on original sources.