Can IL-23 Drugs for Crohn's Start at Home?
Some Crohn's drugs already start with injections or a pill, but most IL-23 drugs still begin with clinic or hospital infusions. AbbVie wants to change that for Skyrizi, after its AFFIRM trial showed that starting with injections works.
Humira, Cimzia and Rinvoq already start at home, but most IL-23 drugs, among the higher-efficacy Crohn's options, still begin with infusions. Tremfya already offers injections from the first dose; AbbVie has filed the same for Skyrizi after its Phase 3 AFFIRM trial met both week-12 goals (clinical remission 55% vs 29.6%; endoscopic response 44% vs 14.3%); Omvoh still needs an infusion. A table of how every advanced Crohn's drug starts, what AFFIRM showed, and why no trial yet shows whether injections work as well as the infusion.