Data updated: May 26, 2026
ADRENALIN (epinephrine)
Adrenergic alpha-Agonists
Trial Activity: Mature 1 active trials
Cardiovascular
Approved 2012-12-07
Adrenalin is indicated for the emergency treatment of Type 1 allergic reactions, including anaphylaxis resulting from insect stings or bites, foods, drugs, and other allergens, as well as idiopathic or exercise-induced anaphyl
How ADRENALIN Works
This medication works by stimulating both alpha and beta-adrenergic receptors throughout the body. When it binds to these receptors, it increases the strength of the heart's contractions and raises the heart rate while simultaneously narrowing the peripheral blood vessels to increase blood pressure.
Development Insights
NATALIA LOPERA MUNERA conducting 1 trials (33%)
6 indications explored (Moderate)
→ sepsis (1 trials)
→ overcoming the failure of anaesthesia (1 trials)
→ maxillary teeth (1 trials)
4
Indications
--
Phase 3 Trials
13
Years on Market
Details
- Status
- Prescription
- First Approved
- 2012-12-07
- Patent Cliff
- 2039
- Routes
- INTRAMUSCULAR, INTRAVENOUS, SUBCUTANEOUS, INTRAVENOUS
- Dosage Forms
- SOLUTION
ADRENALIN Approval History
2013
2014
2015
2016
2017
2018
2019
2020
2021
2022
2023
2024
2025
2026
Original
New Indication
New Form
Label Update
25 FDA actions from 2012 to 2023 · 1 indication expansions
Mar 2015 SUPPL
Mfg
Jul 2014 SUPPL
Mfg
What ADRENALIN Treats
4 indicationsADRENALIN is approved for 4 conditions since its original approval in 2012. These indications span multiple therapeutic areas including oncology, immunology, and more.
- Anaphylaxis
- Hypotension
- Septic Shock
- Allergic Reactions
Source: FDA Label
ADRENALIN Competitive Set
ProThree rings of competition based on shared molecular targets and treated indications.
Direct competitors
7
Same target(s) AND same indication — head-to-head.
MoA expansion candidates
3
Same target(s), different indications — where else is this mechanism being explored?
Indication competitors
10
Same indication, different mechanism — what else might this patient receive?
Unlock 14 more competitors across all three rings.
Upgrade to Pro Filters applied: drops same-active-ingredient (505(b)(2) reformulations), route-mismatch (topical vs systemic), and cross-therapeutic-area matches in same-indication rings.
Drugs Similar to ADRENALIN
3 of 20FDA-approved drugs for similar conditions. Compare mechanisms and indications to understand treatment alternatives.
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Clinical Trial Registry
59 trials| Trial | Sponsor ID | Phase | Status | Title |
|---|---|---|---|---|
| NCT05738148 | Pro00122275 | Ph 1 | active not recruiting | Vasopressin vs. Epinephrine During Neonatal Cardiopulmonary Resuscitation |
| NCT04432597 | 200104 20-C-0104 | Ph 1, Ph 2 | active not recruiting | HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associated Cancers |
| NCT05488847 results posted | 15592 | Ph 4 | active not recruiting | Opioid-Free Pain Protocol After Shoulder Arthroplasty |
| NCT07092566 | IRB00133736 ONC-GU-2404 | Ph 3 | recruiting | R.E.C.K vs Exparel in Robotic Nephrectomy |
| NCT02118467 | 14-0047 | Ph 4 | recruiting | Vasoactive Drugs in Intensive Care Unit |
| NCT06418308 | STUDY-23-01613 | Ph 4 | recruiting | Intrathecal Dexmedetomidine vs Epinephrine |
| NCT03826524 EpiDOSE | EpiDOSE Protocol Version 3.0 | Ph 4 | recruiting | Epinephrine Dose: Optimal Versus Standard Evaluation Trial |
| NCT02356159 results posted | 150067 15-C-0067 | Ph 1, Ph 2 | completed | Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation |
| NCT02722746 results posted | IRB201600185 | Ph 1, Ph 2 | completed | The Prevention of Hypotension After Epidural Analgesia After Major Surgery |
| NCT01059786 results posted | 100025 10-C-0025 | Ph 2 | active not recruiting | Randomized Phase II Trial of Rituximab With Either Pentostatin or Bendamustine for Multiply Relapsed or Refractory Hairy Cell Leukemia |
| NCT05972681 PAIN | 2023-14825 | Ph 4 | recruiting | The PAIN (Pelvic Area Injection for Numbness) Study |
| NCT03554473 results posted | 180110 18-C-0110 | Ph 1, Ph 2 | completed | M7824 and Topotecan or Temozolomide in Relapsed Small Cell Lung Cancers |
| NCT04032119 | EPI-ESD RCT01 | Ph 3 | completed | RCT of Gastric ESD With or Without Epineprhine Added Solution |
| NCT03476642 results posted | STUDY0008641 | Ph 4 | completed | Distribution, Pharmacokinetics and Extent of Sensory Blockade in ESP Blocks |
| NCT06264596 | 2310-72 | Ph 3 | withdrawn | Epinephrine in Irrigation Fluid for Visualization During Ankle Surgery |
| NCT06013150 | DMC-CL-002 | Ph 1 | completed | Study of Inhaled DMC-IH1 and Intramuscular (EpiPen®) Epinephrine in Healthy Male and Female Participants. |
| NCT06284434 | CHI2311 | Ph 3 | recruiting | Liposomal Bupivacaine Use in Alveolar Bone Graft Patients |
| NCT06478797 ANDES-CHILD | IRB: 00006311 | Ph 2 | not yet recruiting | Early Resuscitation in Paediatric Sepsis Using Inotropes |
| NCT04594408 | PA2018-001 | Ph 4 | completed | Tranexamic Acid to Improve Arthroscopic Visualization in Shoulder Surgery |
| NCT06266962 | 3/24 | Ph 4 | completed | Comparing the Efficiency of Two Approaches in Patients at Risk of Developing Intraoperative Floppy Iris Syndrome |
| NCT02967172 results posted | 201608737 | Ph 4 | completed | Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures |
| NCT04065451 results posted | 1908473351 | Ph 4 | completed | Effect of Epinephrine on Post-polypectomy Pain |
| NCT02980835 | 721921 | Ph 4 | completed | Optimal Timing of Intercostal Nerve Blocks During Video-Assisted Thoracic Surgeries |
| NCT03513445 | ORSU-2018-26340 | Ph 3 | withdrawn | Peri-Incisional Drug Injection in Lumbar Spine Surgery |
| NCT05439460 results posted | 22554 | Ph 4 | completed | Management of Acute Pulmonary Hypertensive Crisis in Children With Known Pulmonary Arterial Hypertension |
| NCT05413902 | A9630120 | Ph 4 | completed | Multi-Modal Anesthesia Protocol in Pain Management of Patients Undergoing Posterior Lumbar Spinal Fusion Surgery |
| NCT05324995 | 394048 | Ph 2 | completed | Peri-Articular-Multimodal Drug and Oral Celecoxib in Management of Postoperative Pain of Total Knee Arthroplasty |
| NCT02570503 results posted | HM20004125 | Ph 4 | terminated | Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty |
| NCT02740127 results posted | 2014-0990 NCI-2016-00860 | Ph 3 | completed | Evaluate Use of Caudal Nerve Blocks in Adult Penile Prosthesis |
| NCT03228914 results posted | HSC-MS-17-0415 | Ph 4 | completed | Comparing Blood Loss and Visualization After the Preoperative Use of Topical 0.05% Oxymetazoline Versus 1:1000 Epinephrine Prior to Endoscopic Sinus Surgery |
| NCT02895035 results posted | 00005630 | Ph 4 | terminated | Comparison of Epinephrine and Phenylephrine/Ketorolac With Regards to Pupil Size |
| NCT04236115 | Taibah dental College | Ph 4 | completed | Comparison of Articaine and Prilocaine for Extraction of Maxillary Teeth |
| NCT02453516 | 2014-0051-E | Ph 2, Ph 3 | completed | The Effect of the Serratus Block on Pain Control After Breast Surgery |
| NCT03383588 results posted | 2017-8094 | Ph 2 | terminated | Subcutaneous Bupivacaine Decrease Post-op Pain in Patients Undergoing C-Section |
| NCT03163914 | Vasopressor | Ph 4 | completed | Effect of Vasopressors on Spinal Anaesthesia Induced Hypotension |
| NCT02543801 results posted | IRB2022 | Ph 4 | completed | A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty |
| NCT02534571 TC325 | TC325 Study | Ph 3 | completed | To Compare a Hemostatic Powder TC-325 and Standard Treatment in the Control of Acute Upper Gastrointestinal Bleeding From Nonvariceal Causes |
| NCT00628550 Vasopressin | 082007-065 | Ph 1 | completed | Trial of Vasopressin and Epinephrine to Epinephrine Only for In-Hospital Pediatric Cardiopulmonary Resuscitation |
| NCT00890162 results posted | 090129 09-I-0129 | Ph 2 | completed | A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis |
| NCT02365961 results posted | Pro00038232 | Ph 4 | completed | Hip Scope Fascia-iliaca (FI) Block Study |
| NCT02519023 results posted | 7152222222 | Ph 4 | completed | TAP vs Surgical Infiltration of Local Anesthetic in Laparoscopic and Robotic Hysterectomy |
| NCT02474654 | 15-009 | Ph 4 | completed | Implementation of a Pain Management Protocol for Total Knee Arthroplasty |
| NCT02462148 results posted | IRB00032807 | Ph 4 | completed | Perineural Steroids for Peripheral Nerve Blocks |
| NCT02464176 results posted | IRB00032805 | Ph 4 | completed | Systemic Steroids for Peripheral Nerve Blocks |
| NCT03441412 | EudraCT 2017-003111-18 | Ph 1 | completed | A Study of the Effect of Epinephrine on Platelet Reactivity in Subjects Treated With Ticagrelor |
| NCT02658149 results posted | 2015-422 | Ph 4 | completed | Psoas Compartment Block Versus Periarticular Local Anesthetic for Total Hip Arthroplasty |
| NCT02242201 results posted | 14-004183 UL1TR000135 | Ph 4 | completed | Total Hip Arthroplasty (THA) Lumbar Plexus Verses Periarticular |
| NCT02428062 THE BRIDGE | TB-POCD | Ph 2, Ph 3 | suspended | Target Hemodynamics and Brain Injury During General Anesthesia in the Elderly |
| NCT02793947 results posted | 201501822 | Ph 4 | completed | Efficacy of Peri-Incisional Multimodal Drug Injection Following Operative Management of Femur Fractures |
| NCT01759407 results posted | IRB16-00338 | Ph 2 | terminated | Femoral Nerve Block for Femur Fracture Repair in Pediatrics |
Showing 50 of 59 trials
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Ongoing clinical trials by development phase
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Pro Key Completed Trials
Completed studies with published results, ranked by significance
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Trial Timeline
Full development history with FDA approval milestones
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Understanding FDA Approval Types
| Count | Type | What it means |
|---|---|---|
| - | ORIG | Original approval - drug first enters market |
| - | SUPPL - Efficacy | New indication (new disease/condition approved) |
| - | SUPPL - Labeling | Label text changes (warnings, dosing updates) |
| - | SUPPL - Manufacturing | Production changes (new facility) |
| - | SUPPL - Chemistry | Formulation changes (new dosage strength) |
Green lines in the timeline show ORIG and Efficacy approvals - the clinically meaningful milestones.
ADRENALIN FDA Label Details
Indications & Usage
FDA Label (PDF)ADRENALIN is indicated for the treatment of Anaphylaxis; Hypotension; Septic Shock; Allergic Reactions.
View full patent landscape →
8 OB patents · 3 families ·
47 international docs across 8 countries
ADRENALIN Patents & Exclusivity
Latest Patent: Mar 2039
Patents (8 active)
US11083698
Expires Mar 21, 2039
US10653646
Expires Mar 21, 2039
US11207280
Expires Mar 21, 2039
US12133837
Expires Mar 21, 2039
US9295657
Expires Mar 13, 2035
US9119876
Expires Mar 13, 2035
US12280024
Expires Mar 13, 2035
US10130592
Expires Mar 13, 2035
Source: FDA Orange Book
Pro Intelligence Preview
Deep insights for ADRENALIN
Revenue Insights
- • Quarterly revenue tracking
- • Historical trend analysis
Patent Timeline
- • Cliff: 2039
- • 107 active patents
Trial Analysis
- • 3 total trials
- • Stage: Mature
Competitive Landscape
- • 20 similar drugs
- • Same target/indication analysis
Unlock Full Intelligence
Full approval history • All patents • Revenue trends • Competitor analysis
Data Sources
Data sourced from official FDA and NIH databases. Click links to verify on original sources.
How We Calculate These Metrics
Trial Activity Stage
Measures the current development activity pattern based on trial phases, status, and trends. Important: This measures R&D activity, not commercial lifecycle.
Trial statuses: "Active" means recruiting or ongoing. "Completed" means reached planned endpoint. "Terminated" means stopped early—often due to safety, efficacy, or business reasons.
- Growth: High proportion of early-phase trials (Phase 1/2), active development
- Expansion: Significant Phase 3 activity, approaching or pursuing approvals
- Mature: Substantial Phase 4 post-marketing studies
- Stable: Mixed phase distribution, steady development
- Declining: Low active trial ratio, reduced R&D investment