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Eli Lilly Drug Pipeline

Data updated: May 20, 2026

222 active trials across 15 therapeutic areas

Eli Lilly maintains a substantial clinical portfolio, with 219 active trials out of 1493 total registered since 2008. The active pipeline spans from Phase 1 through Phase 4, with 71, 52, 93, and 10 trials respectively. These trials cover 15 therapeutic areas, but are heavily concentrated in Oncology, which accounts for 51% of active programs (111 trials). Metabolic diseases represent the next largest focus with 76 active trials, followed by Immunology (29), CNS (22), Pain (6), and Cardiovascular (5). Within Oncology, the greatest activity is in Solid Tumor (Advanced) indications, with 34 active trials including 7 in Phase 3. Non-small cell lung cancer (NSCLC) is another key area within Oncology, with 17 active trials, 6 of which are in Phase 3. Breast Cancer (8 active, 3 Ph3), Non-Hodgkin Lymphoma (7 active), and Pancreatic Cancer (4 active) also feature in the portfolio. The weighting toward Phase 3 trials in Oncology suggests a focus on near-term clinical catalysts in this therapeutic area.

222
Active Trials
74
Phase 1
51
Phase 2
93
Phase 3
15
Therapeutic Areas
Portfolio Concentration: 50% of active trials in Oncology

Oncology

111 active / 424 total
Solid Tumor (Advanced)
34 active 7 Ph3
131 total since 2008
NSCLC
17 active 6 Ph3
73 total since 2008
Breast Cancer
8 active 3 Ph3
30 total since 2008
Non-Hodgkin Lymphoma
7 active
20 total since 2008
Pancreatic Cancer
4 active
12 total since 2008
Prostate Cancer
4 active 1 Ph3
11 total since 2008
Colorectal Cancer
3 active
16 total since 2008
Hematologic Malignancies
3 active
7 total since 2008
Cholangiocarcinoma
3 active
6 total since 2008
Triple Negative Breast Cancer
3 active
5 total since 2008
Thyroid Cancer
3 active
3 total since 2008
CLL
3 active
3 total since 2008
Sarcoma
2 active
13 total since 2008
Ovarian Cancer
2 active
8 total since 2008
Head and Neck Cancer
2 active
5 total since 2008
Esophageal Cancer
2 active
4 total since 2008
Cervical Cancer
2 active
3 total since 2008
Bladder Cancer
2 active
3 total since 2008
Brain Tumor
2 active
3 total since 2008
SCLC
1 active
7 total since 2008
Multiple Myeloma
1 active
4 total since 2008
AML
1 active
3 total since 2008
MDS
1 active
2 total since 2008
Endometrial Cancer
1 active
1 total since 2008
Gastric Cancer
0 active
15 total since 2008
Hepatocellular Carcinoma
0 active
12 total since 2008
Melanoma
0 active
7 total since 2008
Renal Cell Carcinoma
0 active
6 total since 2008
Lung Cancer (General)
0 active
3 total since 2008
Neuroendocrine Tumors
0 active
2 total since 2008
Myelofibrosis
0 active
2 total since 2008
Glioblastoma
0 active
1 total since 2008
Mesothelioma
0 active
1 total since 2008
ALL
0 active
1 total since 2008
Squamous Cell Carcinoma
0 active
1 total since 2008

Eli Lilly — Active Trials by Therapeutic Area

Oncology
111
Metabolic
74
Immunology
28
CNS
26
Pain
6
Cardiovascular
5
Musculoskeletal
4
Renal
3

TheraRadar.com

Full Therapeutic Area Breakdown

14 more therapeutic areas: Metabolic, Immunology, CNS, Pain, Cardiovascular and 9 more.

Active Trials by Phase

Phase 1
74
Phase 2
51
Phase 3
93
Phase 4
10

Top 10 Indications (active)

Obesity
48
Solid Tumor (Advanced)
34
Type 2 Diabetes
19
NSCLC
17
Alzheimer's Disease
12
Breast Cancer
8
Ulcerative Colitis
8
Non-Hodgkin Lymphoma
7
Type 1 Diabetes
6
Crohn's Disease
6

Total Trials by TA (lifetime)

Oncology
424
Metabolic
369
Immunology
135
CNS
157
Pain
19
Cardiovascular
19

Metabolic

74 active / 369 total
Obesity
48 active 29 Ph3
96 total since 2008
Type 2 Diabetes
19 active 6 Ph3
186 total since 2008
Type 1 Diabetes
6 active 4 Ph3
52 total since 2008
Diabetes (General)
1 active
19 total since 2008
Dyslipidemia
0 active
8 total since 2008
Diabetic Complications
0 active
6 total since 2008
NASH/NAFLD
0 active
2 total since 2008

Immunology

28 active / 135 total
Ulcerative Colitis
8 active 5 Ph3
13 total since 2008
Crohn's Disease
6 active 4 Ph3
8 total since 2008
Atopic Dermatitis
5 active 4 Ph3
29 total since 2008
Rheumatoid Arthritis
4 active
33 total since 2008
Psoriasis
2 active 1 Ph3
34 total since 2008
Psoriatic Arthritis
2 active 1 Ph3
7 total since 2008
Lupus
1 active
11 total since 2008

CNS

26 active / 157 total
Alzheimer's Disease
12 active 8 Ph3
44 total since 2008
Alcohol Use Disorder
3 active 2 Ph3
6 total since 2008
ALS
3 active
3 total since 2008
Migraine
2 active 2 Ph3
32 total since 2008
Major Depression
1 active 1 Ph3
39 total since 2008
Schizophrenia
1 active
7 total since 2008
Bipolar Disorder
1 active
4 total since 2008
Multiple Sclerosis
1 active
3 total since 2008
Parkinson's Disease
1 active
2 total since 2008
Opioid Use Disorder
1 active
1 total since 2008
ADHD
0 active
12 total since 2008
Anxiety
0 active
3 total since 2008
Neuropathy
0 active
1 total since 2008

Pain

6 active / 19 total
Acute Pain
3 active 1 Ph3
11 total since 2008
Neuropathic Pain
3 active
8 total since 2008

Cardiovascular

5 active / 19 total
Hypertension
4 active 3 Ph3
8 total since 2008
Heart Failure
1 active
4 total since 2008
Coronary Artery Disease
0 active
7 total since 2008

Musculoskeletal

4 active / 28 total
Osteoarthritis
4 active 3 Ph3
16 total since 2008
Osteoporosis
0 active
12 total since 2008

Renal

3 active / 12 total
Chronic Kidney Disease
3 active 2 Ph3
12 total since 2008

Dermatology

3 active / 5 total
Alopecia
2 active 1 Ph3
4 total since 2008
Vitiligo
1 active
1 total since 2008

Gastrointestinal

3 active / 3 total
Diarrhea
1 active
1 total since 2008
Constipation
1 active
1 total since 2008
Nausea/Vomiting
1 active
1 total since 2008

Respiratory

2 active / 3 total
Allergic Rhinitis
1 active 1 Ph3
1 total since 2008
Asthma
1 active
1 total since 2008
Pneumonia
0 active
1 total since 2008

Urology

1 active / 25 total
Overactive Bladder
1 active 1 Ph3
1 total since 2008
Erectile Dysfunction
0 active
12 total since 2008
Benign Prostatic Hyperplasia
0 active
12 total since 2008

Rare Disease

1 active / 6 total
Immune Thrombocytopenia
1 active
1 total since 2008
Sickle Cell Disease
0 active
4 total since 2008
Hemophilia
0 active
1 total since 2008

Infectious Disease

0 active / 9 total
COVID-19
0 active
8 total since 2008
Sepsis
0 active
1 total since 2008

Sleep

0 active / 4 total
Insomnia
0 active
4 total since 2008

Eli Lilly's Full Pipeline

See every therapeutic area, every indication, every active trial across Eli Lilly's portfolio.

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Data: ClinicalTrials.gov · Trials registered 2008 onwards.