Competitive Density
Data updated: Nov 12, 2026
Active trials by therapeutic area and indication
Density Legend (based on active Phase 3 trials & sponsor count)
Hot (crowded)
Warm (competitive)
Cool (moderate)
Cold (sparse)
Oncology
23085 active trialsSolid Tumor (Advanced)
Ph3: 402 • Ph2: 1880 • 818 sponsors
Breast Cancer
Ph3: 338 • Ph2: 942 • 202 sponsors
NSCLC
Ph3: 299 • Ph2: 929 • 337 sponsors
Colorectal Cancer
Ph3: 203 • Ph2: 767 • 244 sponsors
Non-Hodgkin Lymphoma
Ph3: 192 • Ph2: 1085 • 230 sponsors
Prostate Cancer
Ph3: 168 • Ph2: 533 • 158 sponsors
Multiple Myeloma
Ph3: 125 • Ph2: 398 • 90 sponsors
Hepatocellular Carcinoma
Ph3: 98 • Ph2: 399 • 121 sponsors
Ovarian Cancer
Ph3: 95 • Ph2: 300 • 172 sponsors
Bladder Cancer
Ph3: 87 • Ph2: 265 • 109 sponsors
Gastric Cancer
Ph3: 84 • Ph2: 329 • 127 sponsors
AML
Ph3: 83 • Ph2: 373 • 117 sponsors
Lung Cancer (General)
Ph3: 82 • Ph2: 345 • 107 sponsors
Pancreatic Cancer
Ph3: 78 • Ph2: 434 • 203 sponsors
Esophageal Cancer
Ph3: 77 • Ph2: 285 • 88 sponsors
Melanoma
Ph3: 64 • Ph2: 314 • 140 sponsors
Hematologic Malignancies
Ph3: 62 • Ph2: 332 • 84 sponsors
Head and Neck Cancer
Ph3: 59 • Ph2: 353 • 153 sponsors
Triple Negative Breast Cancer
Ph3: 49 • Ph2: 221 • 102 sponsors
Cervical Cancer
Ph3: 48 • Ph2: 161 • 73 sponsors
ALL
Ph3: 48 • Ph2: 236 • 51 sponsors
SCLC
Ph3: 47 • Ph2: 184 • 85 sponsors
Squamous Cell Carcinoma
Ph3: 42 • Ph2: 238 • 50 sponsors
MDS
Ph3: 41 • Ph2: 235 • 83 sponsors
CLL
Ph3: 41 • Ph2: 164 • 47 sponsors
Cholangiocarcinoma
Ph3: 37 • Ph2: 216 • 64 sponsors
Endometrial Cancer
Ph3: 35 • Ph2: 145 • 96 sponsors
Renal Cell Carcinoma
Ph3: 35 • Ph2: 186 • 81 sponsors
Brain Tumor
Ph3: 35 • Ph2: 154 • 58 sponsors
Glioblastoma
Ph3: 31 • Ph2: 214 • 83 sponsors
HER2+ Breast Cancer
Ph3: 28 • Ph2: 74 • 22 sponsors
Sarcoma
Ph3: 26 • Ph2: 293 • 67 sponsors
Neuroendocrine Tumors
Ph3: 22 • Ph2: 80 • 27 sponsors
Thyroid Cancer
Ph3: 20 • Ph2: 59 • 19 sponsors
HER2- Breast Cancer
Ph3: 18 • Ph2: 81 • 29 sponsors
Myelofibrosis
Ph3: 15 • Ph2: 62 • 29 sponsors
Hodgkin Lymphoma
Ph3: 14 • Ph2: 114 • 17 sponsors
CML
Ph3: 9 • Ph2: 80 • 15 sponsors
Merkel Cell Carcinoma
Ph3: 4 • Ph2: 34 • 15 sponsors
Mesothelioma
Ph3: 2 • Ph2: 60 • 36 sponsors
CNS
2271 active trialsAlzheimer's Disease
Ph3: 87 • Ph2: 184 • 96 sponsors
Major Depression
Ph3: 81 • Ph2: 171 • 44 sponsors
Multiple Sclerosis
Ph3: 54 • Ph2: 74 • 38 sponsors
Migraine
Ph3: 42 • Ph2: 21 • 17 sponsors
Schizophrenia
Ph3: 36 • Ph2: 47 • 39 sponsors
Epilepsy
Ph3: 26 • Ph2: 28 • 25 sponsors
Opioid Use Disorder
Ph3: 26 • Ph2: 44 • 11 sponsors
Anxiety
Ph3: 25 • Ph2: 46 • 16 sponsors
Parkinson's Disease
Ph3: 23 • Ph2: 97 • 66 sponsors
ALS
Ph3: 19 • Ph2: 48 • 48 sponsors
Neuropathy
Ph3: 19 • Ph2: 39 • 17 sponsors
Alcohol Use Disorder
Ph3: 18 • Ph2: 72 • 8 sponsors
Autism Spectrum Disorder
Ph3: 16 • Ph2: 50 • 13 sponsors
PTSD
Ph3: 16 • Ph2: 52 • 6 sponsors
Bipolar Disorder
Ph3: 15 • Ph2: 15 • 10 sponsors
ADHD
Ph3: 12 • Ph2: 12 • 5 sponsors
Huntington's Disease
Ph3: 6 • Ph2: 12 • 11 sponsors
OCD
Ph3: 2 • Ph2: 13 • 1 sponsors
Metabolic
1587 active trialsObesity
Ph3: 171 • Ph2: 171 • 97 sponsors
Type 2 Diabetes
Ph3: 93 • Ph2: 81 • 72 sponsors
Diabetes (General)
Ph3: 45 • Ph2: 63 • 37 sponsors
Dyslipidemia
Ph3: 36 • Ph2: 26 • 39 sponsors
Diabetic Complications
Ph3: 32 • Ph2: 46 • 44 sponsors
Type 1 Diabetes
Ph3: 30 • Ph2: 68 • 27 sponsors
NASH/NAFLD
Ph3: 26 • Ph2: 56 • 28 sponsors
Immunology
1577 active trialsAtopic Dermatitis
Ph3: 52 • Ph2: 69 • 79 sponsors
Psoriasis
Ph3: 47 • Ph2: 36 • 53 sponsors
Crohn's Disease
Ph3: 43 • Ph2: 54 • 33 sponsors
Lupus
Ph3: 39 • Ph2: 90 • 101 sponsors
Ulcerative Colitis
Ph3: 37 • Ph2: 75 • 51 sponsors
Myasthenia Gravis
Ph3: 34 • Ph2: 20 • 29 sponsors
IgA Nephropathy
Ph3: 30 • Ph2: 41 • 39 sponsors
Psoriatic Arthritis
Ph3: 23 • Ph2: 13 • 21 sponsors
Rheumatoid Arthritis
Ph3: 21 • Ph2: 61 • 61 sponsors
Hidradenitis Suppurativa
Ph3: 14 • Ph2: 25 • 25 sponsors
Chronic Spontaneous Urticaria
Ph3: 13 • Ph2: 16 • 19 sponsors
NMOSD
Ph3: 10 • Ph2: 12 • 9 sponsors
Lupus Nephritis
Ph3: 9 • Ph2: 37 • 36 sponsors
Sjogren's Disease
Ph3: 6 • Ph2: 27 • 25 sponsors
Ankylosing Spondylitis
Ph3: 6 • Ph2: 8 • 11 sponsors
IBD
Ph3: 4 • Ph2: 11 • 13 sponsors
Cardiovascular
1570 active trialsStroke
Ph3: 174 • Ph2: 120 • 56 sponsors
Hypertension
Ph3: 98 • Ph2: 111 • 93 sponsors
Heart Failure
Ph3: 75 • Ph2: 95 • 47 sponsors
Atrial Fibrillation
Ph3: 44 • Ph2: 21 • 12 sponsors
Coronary Artery Disease
Ph3: 41 • Ph2: 33 • 30 sponsors
Myocardial Infarction
Ph3: 29 • Ph2: 23 • 15 sponsors
Thrombosis
Ph3: 28 • Ph2: 7 • 9 sponsors
Hypertrophic Cardiomyopathy
Ph3: 10 • Ph2: 8 • 10 sponsors
Arrhythmia
Ph3: 8 • Ph2: 8 • 3 sponsors
Infectious Disease
1228 active trialsHIV
Ph3: 70 • Ph2: 114 • 17 sponsors
COVID-19
Ph3: 49 • Ph2: 72 • 43 sponsors
Tuberculosis
Ph3: 41 • Ph2: 36 • 14 sponsors
Sepsis
Ph3: 34 • Ph2: 34 • 7 sponsors
Influenza
Ph3: 31 • Ph2: 21 • 26 sponsors
RSV
Ph3: 20 • Ph2: 26 • 27 sponsors
Hepatitis B
Ph3: 18 • Ph2: 53 • 36 sponsors
Malaria
Ph3: 15 • Ph2: 20 • 8 sponsors
H. pylori
Ph3: 14 • Ph2: 8 • 4 sponsors
Fungal Infections
Ph3: 10 • Ph2: 12 • 9 sponsors
C. difficile
Ph3: 6 • Ph2: 8 • 5 sponsors
Bacterial Infections
Ph3: 5 • Ph2: 6 • 8 sponsors
Hepatitis C
Ph3: 2 • Ph2: 4 • 1 sponsors
Pain
784 active trialsRespiratory
655 active trialsAsthma
Ph3: 56 • Ph2: 70 • 51 sponsors
COPD
Ph3: 41 • Ph2: 58 • 48 sponsors
Pneumonia
Ph3: 41 • Ph2: 21 • 23 sponsors
Idiopathic Pulmonary Fibrosis
Ph3: 24 • Ph2: 46 • 41 sponsors
Chronic Rhinosinusitis with Nasal Polyps
Ph3: 19 • Ph2: 17 • 18 sponsors
Allergic Rhinitis
Ph3: 17 • Ph2: 13 • 19 sponsors
Cystic Fibrosis
Ph3: 10 • Ph2: 15 • 12 sponsors
Rare Disease
440 active trialsImmune Thrombocytopenia
Ph3: 37 • Ph2: 87 • 39 sponsors
Hemophilia
Ph3: 31 • Ph2: 14 • 24 sponsors
Sickle Cell Disease
Ph3: 23 • Ph2: 62 • 18 sponsors
Duchenne Muscular Dystrophy
Ph3: 9 • Ph2: 33 • 27 sponsors
Spinal Muscular Atrophy
Ph3: 9 • Ph2: 10 • 12 sponsors
Fabry Disease
Ph3: 8 • Ph2: 5 • 10 sponsors
Gaucher Disease
Ph3: 3 • Ph2: 8 • 7 sponsors
CDKL5 Deficiency Disorder
Ph3: 2 • Ph2: 0 • 2 sponsors
Mastocytosis
Ph3: 1 • Ph2: 4 • 4 sponsors
Musculoskeletal
320 active trialsOphthalmology
287 active trialsRenal
249 active trialsGastrointestinal
243 active trialsDermatology
193 active trialsWomen's Health
191 active trialsHepatology
120 active trialsUrology
116 active trialsSleep
77 active trialsEndocrine
48 active trialsHot = Crowded space, many late-stage competitors
Cold = Less competition, potential opportunity or difficult indication